Our objective is to provide an unparalleled, centralized, publicly available resource with comprehensive, expertly annotated data, and analysis tools that informs design and interpretation of environmental health studies and promotes novel insights into the etiologies of environmentally influenced diseases. Most human diseases involve interactions between genetic and environmental factors. The environment is implicated in many common conditions such as asthma, cancer, and diabetes; however, the etiology of these widespread diseases remains unclear. More than 80,000 chemicals are currently used in commerce, challenging elucidation about chemical mechanisms of action and prioritization of environmental research. Integration of diverse data with novel analysis approaches is required to understand environment- disease associations and is essential for improving toxicity prediction, risk assessment, regulation and development of effective therapeutic interventions. We developed the Comparative Toxicogenomics Database (CTD; http://ctdbase.org) to enhance understanding about environment-disease connections by providing manually curated data describing chemical-gene interactions and chemical- and gene-disease relationships from the peer-reviewed literature and integrating these data with select external data sets (e.g., pathways and biological process data) and novel data analysis tools. Since its initial public release in 2004, CTD has become a well-established resource with a strong and expanding user base. This competitive renewal proposes to leverage and enhance the existing CTD framework, and continue our tradition of responding to the evolving needs of the environmental health research community by a) increasing the depth of content through comprehensive curation of our ?core? (chemical-gene/protein-disease) and exposure data, b) incorporating select public data sets to augment mechanism-based environmental health analyses, and c) developing and integrating novel analytical and visualization tools. These additions will significantly increase the impact of CTD on environmental health research by centralizing, harmonizing, and contextualizing information required to understand the complex relationships between diverse exposures and environmentally influenced diseases.

Public Health Relevance

Despite the thousands of chemicals used in commerce, our understanding of their effects on human health is not well understood. The Comparative Toxicogenomics Database (CTD) is a unique, publicly available resource that provides information about human exposures and how these exposures influence our genes, our biology, and ultimately our health. This project will build on our established infrastructure to expand the data content and analysis capabilities of CTD to provide new insights into the complex relationship between our environment and human diseases.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Project (R01)
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Biodata Management and Analysis Study Section (BDMA)
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Duncan, Christopher Gentry
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North Carolina State University Raleigh
Schools of Arts and Sciences
United States
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Davis, Allan Peter; Wiegers, Thomas C; Wiegers, Jolene et al. (2018) Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways. Toxicol Sci 165:145-156
Grondin, Cynthia J; Davis, Allan Peter; Wiegers, Thomas C et al. (2018) Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database. Environ Health Perspect 126:014501
Davis, Allan Peter; Grondin, Cynthia J; Johnson, Robin J et al. (2018) The Comparative Toxicogenomics Database: update 2019. Nucleic Acids Res :
Planchart, Antonio; Green, Adrian; Hoyo, Cathrine et al. (2018) Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies. Curr Environ Health Rep 5:110-124
Leung, Maxwell C K; Procter, Andrew C; Goldstone, Jared V et al. (2017) Applying evolutionary genetics to developmental toxicology and risk assessment. Reprod Toxicol 69:174-186
Davis, Allan Peter; Grondin, Cynthia J; Johnson, Robin J et al. (2017) The Comparative Toxicogenomics Database: update 2017. Nucleic Acids Res 45:D972-D978
Manrai, Arjun K; Cui, Yuxia; Bushel, Pierre R et al. (2017) Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health. Annu Rev Public Health 38:279-294
Li, Jiao; Sun, Yueping; Johnson, Robin J et al. (2016) BioCreative V CDR task corpus: a resource for chemical disease relation extraction. Database (Oxford) 2016:
Mattingly, Carolyn J; Boyles, Rebecca; Lawler, Cindy P et al. (2016) Laying a Community-Based Foundation for Data-Driven Semantic Standards in Environmental Health Sciences. Environ Health Perspect 124:1136-40
Grondin, Cynthia J; Davis, Allan Peter; Wiegers, Thomas C et al. (2016) Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database. Environ Health Perspect 124:1592-1599

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