The research proposed here has three main goals. The first is the continuing study of the normal development of visual sensitivity, binocular function and oculomotor control in infants and children of both sexes. The second is the delineation of the correlative changes in the several meaures of sensitivity and oculomotor function in order to model the development of the visual system and to relate this model to the development of the underlying neuronal mechanisms. The third is the production of computer-automated procedures for testing visual function in the both the laboratory and the clinic and computerized database management of research data and subject pool. The detailed projects include: 1. Studies of the relative rates of development of the binocular functions of stereoacuity, fusion and rivalry, and brightness summation of the pupillary response. Modeling the developing binocular system in conjunction with current knowlege of neuronal function. 2. Measures of the normal development of binocular oculomotor control of eye alignment and accommodation for clear single binocular vision, and the correlation of these measures with the development of binocular visual function. 3. Quantification of development in sensitivity to changes in edge orientation. 4. Studies of variation in vernier acuity as a function of meridional variation in edge orientation. 5. Measurement of the course of development of acuity in the periphery of the retina. 6. Establishment of a computerized database and subject pool. 7. Automation of visual testing procedures to increase efficiency and clinical usefulness.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY001191-13
Application #
3255748
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1980-09-01
Project End
1990-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
13
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Deng, Li; Gwiazda, Jane E (2012) Anisometropia in children from infancy to 15 years. Invest Ophthalmol Vis Sci 53:3782-7
Deng, Li; Gwiazda, Jane (2011) Birth season, photoperiod, and infancy refraction. Optom Vis Sci 88:383-7
Deng, Li; Gwiazda, Jane; Thorn, Frank (2010) Children's refractions and visual activities in the school year and summer. Optom Vis Sci 87:406-13
Thorn, Frank; Gwiazda, Jane; Held, Richard (2005) Myopia progression is specified by a double exponential growth function. Optom Vis Sci 82:286-97
Thorn, Frank; Cruz, Antonio A V; Machado, Andre J et al. (2005) Refractive status of indigenous people in the northwestern Amazon region of Brazil. Optom Vis Sci 82:267-72
Gwiazda, Jane; Thorn, Frank; Held, Richard (2005) Accommodation, accommodative convergence, and response AC/A ratios before and at the onset of myopia in children. Optom Vis Sci 82:273-8
Vera-Diaz, Fuensanta A; Gwiazda, Jane; Thorn, Frank et al. (2004) Increased accommodation following adaptation to image blur in myopes. J Vis 4:1111-9
He, Ji C; Gwiazda, Jane; Thorn, Frank et al. (2003) Wave-front aberrations in the anterior corneal surface and the whole eye. J Opt Soc Am A Opt Image Sci Vis 20:1155-63
He, Ji C; Gwiazda, Jane; Thorn, Frank et al. (2003) Change in corneal shape and corneal wave-front aberrations with accommodation. J Vis 3:456-63
He, Ji C; Sun, Pei; Held, Richard et al. (2002) Wavefront aberrations in eyes of emmetropic and moderately myopic school children and young adults. Vision Res 42:1063-70

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