This Competitive Revision is submitted in response to the notice NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. This application expands the scope and the methodology of the parent grant """"""""Visual/Spatial Properties of Posterior Parietal Neurons"""""""" to include two additional research aims. Most of the current knowledge about neural mechanisms underlying eye-hand coordination and selection of movement plans has been derived from electrophysiological recordings in non-human primates, and more recently from fMRI experiments in humans. In order to be able to integrate those findings, it is necessary to study both species by means of the same method, especially because results from the two techniques have not always led to the same conclusions. The current grant revision aims to elucidate the discrepancy between monkey and human studies concerning the degree of overlap between hand and eye signals within the frontoparietal network. Specifically, we will investigate how spatial and effector choices are represented in the monkey brain by applying event-related fMRI while monkeys are choosing either between spatial target positions (i.e. left vs. right) or between different effectors (i.e. eye vs. hand). In addition, we will expand ongoing neurophysiological experiments by investigating how spatial choice preferences originating either from internal or external factors are represented by different areas in the brain. This revision adheres to the goals of the Recovery Act. It will entail retaining a current senior postdoc employee, hiring a new postdoc, a new technician, and a new part-time RF engineer. It will invest in the new technology essential to expand the goals of the project, by acquiring advanced MR-compatible equipment from domestic companies.

Public Health Relevance

The results of the proposed studies can be used to help design therapies for patients suffering from damage to frontal and parietal cortex from strokes and traumatic brain injuries. Application of functional imaging in monkeys, as routinely is done in human patients and healthy subjects, will facilitate the understanding of normal cortical functions and deficits that result from neurological diseases, and can guide the diagnoses and treatments for these diseases

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Special Emphasis Panel (ZRG1-IFCN-B (95))
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Steinmetz, Michael A
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California Institute of Technology
Schools of Arts and Sciences
United States
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Graf, Arnulf B A; Andersen, Richard A (2015) Predicting oculomotor behaviour from correlated populations of posterior parietal neurons. Nat Commun 6:6024
Andersen, Richard A; Andersen, Kristen N; Hwang, Eun Jung et al. (2014) Optic ataxia: from Balint's syndrome to the parietal reach region. Neuron 81:967-983
Andersen, Richard A; Kellis, Spencer; Klaes, Christian et al. (2014) Toward more versatile and intuitive cortical brain-machine interfaces. Curr Biol 24:R885-R897
Hwang, Eun Jung; Hauschild, Markus; Wilke, Melanie et al. (2014) Spatial and temporal eye-hand coordination relies on the parietal reach region. J Neurosci 34:12884-92
Bremner, Lindsay R; Andersen, Richard A (2014) Temporal analysis of reference frames in parietal cortex area 5d during reach planning. J Neurosci 34:5273-84
Graf, Arnulf Ba; Andersen, Richard A (2014) Inferring eye position from populations of lateral intraparietal neurons. Elife 3:e02813
Graf, Arnulf B A; Andersen, Richard A (2014) Brain-machine interface for eye movements. Proc Natl Acad Sci U S A 111:17630-5
Buneo, Christopher A; Andersen, Richard A (2012) Integration of target and hand position signals in the posterior parietal cortex: effects of workspace and hand vision. J Neurophysiol 108:187-99
Hwang, Eun Jung; Hauschild, Markus; Wilke, Melanie et al. (2012) Inactivation of the parietal reach region causes optic ataxia, impairing reaches but not saccades. Neuron 76:1021-9
Bremner, Lindsay R; Andersen, Richard A (2012) Coding of the reach vector in parietal area 5d. Neuron 75:342-51

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