Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008148-06
Application #
2162058
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1988-09-01
Project End
1996-11-30
Budget Start
1995-07-01
Budget End
1996-11-30
Support Year
6
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Bassnett, Steven; Costello, M Joseph (2017) The cause and consequence of fiber cell compaction in the vertebrate lens. Exp Eye Res 156:50-57
Costello, M Joseph; Brennan, Lisa A; Mohamed, Ashik et al. (2016) Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells. PLoS One 11:e0160785
Costello, M Joseph; Brennan, Lisa A; Basu, Subharsee et al. (2013) Autophagy and mitophagy participate in ocular lens organelle degradation. Exp Eye Res 116:141-50
Mohamed, Ashik; Gilliland, Kurt O; Metlapally, Sangeetha et al. (2013) Simple fixation and storage protocol for preserving the internal structure of intact human donor lenses and extracted human nuclear cataract specimens. Mol Vis 19:2352-9
Costello, M Joseph; Mohamed, Ashik; Gilliland, Kurt O et al. (2013) Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction. Exp Eye Res 116:411-8
Costello, M Joseph; Burette, Alain; Weber, Mariko et al. (2012) Electron tomography of fiber cell cytoplasm and dense cores of multilamellar bodies from human age-related nuclear cataracts. Exp Eye Res 101:72-81
Costello, M Joseph; Johnsen, Sonke; Metlapally, Sangeetha et al. (2010) Multilamellar spherical particles as potential sources of excessive light scattering in human age-related nuclear cataracts. Exp Eye Res 91:881-9
Costello, M J; Johnsen, Sonke; Metlapally, Sangeetha et al. (2008) Ultrastructural analysis of damage to nuclear fiber cell membranes in advanced age-related cataracts from India. Exp Eye Res 87:147-58
Metlapally, S; Costello, M J; Gilliland, K O et al. (2008) Analysis of nuclear fiber cell cytoplasmic texture in advanced cataractous lenses from Indian subjects using Debye-Bueche theory. Exp Eye Res 86:434-44
Costello, M Joseph (2006) Cryo-electron microscopy of biological samples. Ultrastruct Pathol 30:361-71