Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
7R01EY010009-02
Application #
3267282
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1993-09-01
Project End
1996-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
02114
Lu, Wennan; Hu, HuiLing; Sévigny, Jean et al. (2015) Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye. Invest Ophthalmol Vis Sci 56:3075-83
Schuettauf, Frank; Stein, Thomas; Choragiewicz, Tomasz J et al. (2011) Caspase inhibitors protect against NMDA-mediated retinal ganglion cell death. Clin Exp Ophthalmol 39:545-54
Zhang, Mei; Budak, Murat T; Lu, Wennan et al. (2006) Identification of the A3 adenosine receptor in rat retinal ganglion cells. Mol Vis 12:937-48
Zhang, Xiulan; Zhang, Mei; Laties, Alan M et al. (2006) Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation. J Neurochem 98:566-75
Reigada, David; Lu, Wennan; Zhang, Xiulan et al. (2005) Degradation of extracellular ATP by the retinal pigment epithelium. Am J Physiol Cell Physiol 289:C617-24
Patel, Anand S; Reigada, David; Mitchell, Claire H et al. (2005) Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation. Am J Physiol Lung Cell Mol Physiol 289:L489-96
Wamsley, Sonja; Gabelt, B'Ann T; Dahl, David B et al. (2005) Vitreous glutamate concentration and axon loss in monkeys with experimental glaucoma. Arch Ophthalmol 123:64-70
Zhang, Xiulan; Zhang, Mei; Laties, Alan M et al. (2005) Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells. Invest Ophthalmol Vis Sci 46:2183-91
Schuettauf, Frank; Zurakowski, David; Quinto, Kristine et al. (2005) Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells. Graefes Arch Clin Exp Ophthalmol 243:1036-42
Kim, Charlene B Y; VerHoeve, James N; Kaufman, Paul L et al. (2005) Effects of reference electrode location on monopolar-derived multifocal electroretinograms in cynomolgus monkeys. Doc Ophthalmol 111:113-25

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