Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM023913-18A1
Application #
2174178
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1977-08-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Liang, Q; Chen, L; Fulco, A J (1998) In vivo roles of Bm3R1 repressor in the barbiturate-mediated induction of the cytochrome P450 genes (P450(BM-3) and P450(BM-)1) of Bacillus megaterium. Biochim Biophys Acta 1380:183-97
Liang, Q; Fulco, A J (1995) Transcriptional regulation of the genes encoding cytochromes P450BM-1 and P450BM-3 in Bacillus megaterium by the binding of Bm3R1 repressor to Barbie box elements and operator sites. J Biol Chem 270:18606-14
He, J S; Liang, Q; Fulco, A J (1995) The molecular cloning and characterization of BM1P1 and BM1P2 proteins, putative positive transcription factors involved in barbiturate-mediated induction of the genes encoding cytochrome P450BM-1 of Bacillus megaterium. J Biol Chem 270:18615-25
Liang, Q; He, J S; Fulco, A J (1995) The role of Barbie box sequences as cis-acting elements involved in the barbiturate-mediated induction of cytochromes P450BM-1 and P450BM-3 in Bacillus megaterium. J Biol Chem 270:4438-50
Liang, Q; Chen, L; Fulco, A J (1995) An efficient and optimized PCR method with high fidelity for site-directed mutagenesis. PCR Methods Appl 4:269-74
Klein, M L; Fulco, A J (1994) The interaction of cytochrome c and the heme domain of cytochrome P-450BM-3 with the reductase domain of cytochrome P-450BM-3. Biochim Biophys Acta 1201:245-50
Shaw, G C; Fulco, A J (1993) Inhibition by barbiturates of the binding of Bm3R1 repressor to its operator site on the barbiturate-inducible cytochrome P450BM-3 gene of Bacillus megaterium. J Biol Chem 268:2997-3004
Klein, M L; Fulco, A J (1993) Critical residues involved in FMN binding and catalytic activity in cytochrome P450BM-3. J Biol Chem 268:7553-61
Shaw, G C; Fulco, A J (1992) Barbiturate-mediated regulation of expression of the cytochrome P450BM-3 gene of Bacillus megaterium by Bm3R1 protein. J Biol Chem 267:5515-26
He, J S; Fulco, A J (1991) A barbiturate-regulated protein binding to a common sequence in the cytochrome P450 genes of rodents and bacteria. J Biol Chem 266:7864-9

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