Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM025418-18
Application #
2174436
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1978-07-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Khojasteh, S Cyrus; Hartley, Dylan P; Ford, Kevin A et al. (2012) Characterization of rat liver proteins adducted by reactive metabolites of menthofuran. Chem Res Toxicol 25:2301-9
Ortiz de Montellano, Paul R; Nelson, Sidney D (2011) Rearrangement reactions catalyzed by cytochrome P450s. Arch Biochem Biophys 507:95-110
Khojasteh, S Cyrus; Oishi, Shimako; Nelson, Sidney D (2010) Metabolism and toxicity of menthofuran in rat liver slices and in rats. Chem Res Toxicol 23:1824-32
Regal, Kelly A; Kunze, Kent L; Peter, Raimund M et al. (2005) Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching. Drug Metab Dispos 33:1837-44
Pierce, Robert H; Franklin, Christopher C; Campbell, Jean S et al. (2002) Cell culture model for acetaminophen-induced hepatocyte death in vivo. Biochem Pharmacol 64:413-24
James, Eric A; Gygi, Steven P; Adams, Michael L et al. (2002) Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine. Biochemistry 41:6789-97
Gartner, C A; Thompson, S J; Rettie, A E et al. (2001) Human aromatase in high yield and purity by perfusion chromatography and its characterization by difference spectroscopy and mass spectrometry. Protein Expr Purif 22:443-54
Adams, M L; Pierce, R H; Vail, M E et al. (2001) Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2. Mol Pharmacol 60:907-15
Regal, K A; Nelson, S D (2000) Orientation of caffeine within the active site of human cytochrome P450 1A2 based on NMR longitudinal (T1) relaxation measurements. Arch Biochem Biophys 384:47-58
Chen, W; Shockcor, J P; Tonge, R et al. (1999) Protein and nonprotein cysteinyl thiol modification by N-acetyl-p-benzoquinone imine via a novel ipso adduct. Biochemistry 38:8159-66

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