Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM035401-10
Application #
2177889
Study Section
Physiology Study Section (PHY)
Project Start
1985-09-06
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Xiao, Yong-Fu; Ke, Qingen; Wang, Sho-Ya et al. (2004) Electrophysiologic properties of lidocaine, cocaine, and n-3 fatty-acids block of cardiac Na+ channels. Eur J Pharmacol 485:31-41
Sudoh, Yukari; Desai, Sukumar P; Haderer, Anna E et al. (2004) Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline. Reg Anesth Pain Med 29:434-40
Nau, Carla; Wang, Sho-Ya; Wang, Ging Kuo (2003) Point mutations at L1280 in Nav1.4 channel D3-S6 modulate binding affinity and stereoselectivity of bupivacaine enantiomers. Mol Pharmacol 63:1398-406
O'Reilly, J P; Wang, S Y; Wang, G K (2003) Methanethiosulfonate-modification alters local anesthetic block in rNav1.4 cysteine-substituted mutants S1276C and L1280C. J Membr Biol 193:47-55
Wang, Ging Kuo; Wang, Sho-Ya (2003) Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule. J Physiol 548:667-75
Sudoh, Yukari; Cahoon, Elaine Elliott; Gerner, Peter et al. (2003) Tricyclic antidepressants as long-acting local anesthetics. Pain 103:49-55
Wang, G K; Wang, S Y (2002) Modifications of human cardiac sodium channel gating by UVA light. J Membr Biol 189:153-65
Xiao, Y F; Ke, Q; Wang, S Y et al. (2001) Point mutations in alpha-subunit of human cardiac Na+ channels alter Na+ current kinetics. Biochem Biophys Res Commun 281:45-52
Xiao, Y F; Ke, Q; Wang, S Y et al. (2001) Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. Proc Natl Acad Sci U S A 98:3606-11
Wang, S Y; Barile, M; Wang, G K (2001) A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyrethroid action. Mol Pharmacol 60:620-8

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