Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM036562-04S1
Application #
3290787
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1990-02-01
Project End
1992-03-31
Budget Start
1990-02-01
Budget End
1990-03-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Brown University
Department
Type
Schools of Arts and Sciences
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Anderson, Vernon E (2005) Quantifying energetic contributions to ground state destabilization. Arch Biochem Biophys 433:27-33
Bahnson, Brian J; Anderson, Vernon E; Petsko, Gregory A (2002) Structural mechanism of enoyl-CoA hydratase: three atoms from a single water are added in either an E1cb stepwise or concerted fashion. Biochemistry 41:2621-9
Liu, Binqiu; Wang, Yingqiang; Fillgrove, Kerry L et al. (2002) Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells. Cancer Chemother Pharmacol 49:187-93
Fillgrove, K L; Anderson, V E (2001) The mechanism of dienoyl-CoA reduction by 2,4-dienoyl-CoA reductase is stepwise: observation of a dienolate intermediate. Biochemistry 40:12412-21
Goshe, M B; Chen, Y H; Anderson, V E (2000) Identification of the sites of hydroxyl radical reaction with peptides by hydrogen/deuterium exchange: prevalence of reactions with the side chains. Biochemistry 39:1761-70
Fillgrove, K L; Anderson, V E (2000) Orientation of coenzyme A substrates, nicotinamide and active site functional groups in (Di)enoyl-coenzyme A reductases. Biochemistry 39:7001-11
Baker-Malcolm, J F; Lantz, M; Anderson, V E et al. (2000) Novel inactivation of enoyl-CoA hydratase via beta-elimination of 5, 6-dichloro-7,7,7-trifluoro-4-thia-5-heptenoyl-CoA. Biochemistry 39:12007-18
Kean, E L; Wei, Z; Anderson, V E et al. (1999) Regulation of the biosynthesis of N-acetylglucosaminylpyrophosphoryldolichol, feedback and product inhibition. J Biol Chem 274:34072-82
Fillgrove, K L; Anderson, V E; Mizugaki, M (1999) Cloning, expression, and purification of the functional 2,4-dienoyl-CoA reductase from rat liver mitochondria. Protein Expr Purif 17:57-63
Fedoriw, A M; Liu, H; Anderson, V E et al. (1998) Equilibrium and kinetic parameters of the sequence-specific interaction of Escherichia coli RNA polymerase with nontemplate strand oligodeoxyribonucleotides. Biochemistry 37:11971-9

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