Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM044592-03S1
Application #
3303781
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1990-07-01
Project End
1995-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Sun, Xianqiang; Singh, Sukrit; Blumer, Kendall J et al. (2018) Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding. Elife 7:
Onken, Michael D; Makepeace, Carol M; Kaltenbronn, Kevin M et al. (2018) Targeting nucleotide exchange to inhibit constitutively active G protein ? subunits in cancer cells. Sci Signal 11:
Scherer, Stephanie L; Cain, Matthew D; Kanai, Stanley M et al. (2017) Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit G?13. J Biol Chem 292:9906-9918
Kanai, Stanley M; Edwards, Alethia J; Rurik, Joel G et al. (2017) Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction. J Biol Chem 292:19266-19278
Osei-Owusu, Patrick; Blumer, Kendall J (2015) Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function. Prog Mol Biol Transl Sci 133:77-92
Osei-Owusu, Patrick; Owens, Elizabeth A; Jie, Li et al. (2015) Regulation of Renal Hemodynamics and Function by RGS2. PLoS One 10:e0132594
Rensing, Derek T; Uppal, Sakshi; Blumer, Kendall J et al. (2015) Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-254890 Analog. Org Lett 17:2270-3
Oladipupo, Sunday S; Smith, Craig; Santeford, Andrea et al. (2014) Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A 111:13379-84
Osei-Owusu, Patrick; Knutsen, Russell H; Kozel, Beth A et al. (2014) Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency. Am J Physiol Heart Circ Physiol 306:H654-66
Jia, Lixia; Chisari, Mariangela; Maktabi, Mohammad H et al. (2014) A mechanism regulating G protein-coupled receptor signaling that requires cycles of protein palmitoylation and depalmitoylation. J Biol Chem 289:6249-57

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