Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM057440-06
Application #
6689617
Study Section
Special Emphasis Panel (ZRG1-TMP (01))
Program Officer
Shapiro, Bert I
Project Start
1999-01-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
6
Fiscal Year
2004
Total Cost
$224,250
Indirect Cost
Name
Michigan State University
Department
Zoology
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Wu, Shaoying; Nomura, Yoshiko; Du, Yuzhe et al. (2017) Molecular basis of selective resistance of the bumblebee BiNav1 sodium channel to tau-fluvalinate. Proc Natl Acad Sci U S A 114:12922-12927
Chen, Mengli; Du, Yuzhe; Nomura, Yoshiko et al. (2017) Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance. Insect Biochem Mol Biol 82:1-10
Silver, Kristopher; Dong, Ke; Zhorov, Boris S (2017) Molecular Mechanism of Action and Selectivity of Sodium Ch annel Blocker Insecticides. Curr Med Chem 24:2912-2924
Chen, Mengli; Du, Yuzhe; Nomura, Yoshiko et al. (2017) Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids. Neurotoxicology 60:197-206
Haddi, Khalid; Tomé, Hudson V V; Du, Yuzhe et al. (2017) Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control. Sci Rep 7:46549
Zhorov, Boris S; Dong, Ke (2017) Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel. Neurotoxicology 60:171-177
Zhang, Yongqiang; Du, Yuzhe; Jiang, Dingxin et al. (2016) The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides. J Biol Chem 291:20113-24
Du, Yuzhe; Nomura, Yoshiko; Zhorov, Boris S et al. (2016) Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti. Insects 7:
Wang, Xing-Liang; Su, Wen; Zhang, Jian-Heng et al. (2016) Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the diamondback moth, Plutella xylostella. Insect Sci 23:50-8
Du, Yuzhe; Nomura, Yoshiko; Zhorov, Boris S et al. (2016) Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels. J Biol Chem 291:4638-48

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