Angela Castanieto is a strong candidate for the NIGMS Diversity Supplements Program. She is an Hispanic-American graduate student in the UCSF Tetrad PhD program and has already demonstrated an outstanding aptitude for scientific research. In addition, she is very involved with the UCSF community at large and specifically within the Hispanic community at UCSF as a founding member of the UCSF SACNAS chapter. This provides her with the opportunity to interact with people from diverse backgrounds, both as a mentee and a role model. Although Ms. Castanieto is currently in her third year of graduate school, and thus further into her program than the typical candidate for the Diversity Supplements Program, extenuating circumstances have delayed her progress. She arrived at UCSF through a non-traditional path that left her with less experience and preparation in biology than her peers. As a result, she had to retake two of her major first year courses in her second year, and postpone her TA duties until her third year. Unlike her classmates, who started working on their research full-time over a year ago, Ms. Castanieto just completed the last of her nonresearch requirements in December, 2011. Nonetheless, during her short time in the lab, she has obtained compelling preliminary data that suggest a novel mechanism for the regulation of the epithelial stem cell fate in the Drosophila ovary. A one-year supplement would provide Ms. Castanieto with the means to develop her project to the point where she would be competitive for independent support, through mechanisms such as an F31 predoctoral fellowship. Thus, we are requesting a supplement for my R01, titled ?Modeling epithelial stem cell competition in a dynamic Drosophila ovarian niche,? Grant number 5R01GM097158-02.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Project (R01)
Project #
Application #
Study Section
Program Officer
Haynes, Susan R
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Anatomy/Cell Biology
Schools of Medicine
San Francisco
United States
Zip Code
Cook, Matthew S; Cazin, Coralie; Amoyel, Marc et al. (2017) Neutral Competition for Drosophila Follicle and Cyst Stem Cell Niches Requires Vesicle Trafficking Genes. Genetics 206:1417-1428
Ulmschneider, Bryne; Grillo-Hill, Bree K; Benitez, Marimar et al. (2016) Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. J Cell Biol 215:345-355
Johnston, Michael J; Bar-Cohen, Shaked; Paroush, Ze'ev et al. (2016) Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche. Development 143:4631-4642
Vlachos, Stephanie; Jangam, Sharayu; Conder, Ryan et al. (2015) A Pak-regulated cell intercalation event leading to a novel radial cell polarity is involved in positioning of the follicle stem cell niche in the Drosophila ovary. Development 142:82-91
Castanieto, Angela; Johnston, Michael J; Nystul, Todd G (2014) EGFR signaling promotes self-renewal through the establishment of cell polarity in Drosophila follicle stem cells. Elife 3:
Kronen, Maria R; Schoenfelder, Kevin P; Klein, Allon M et al. (2014) Basolateral junction proteins regulate competition for the follicle stem cell niche in the Drosophila ovary. PLoS One 9:e101085
Huang, Pamela; Sahai-Hernandez, Pankaj; Bohm, Rudolf A et al. (2014) Enhancer-trap flippase lines for clonal analysis in the Drosophila ovary. G3 (Bethesda) 4:1693-9
Sahai-Hernandez, Pankaj; Nystul, Todd G (2013) A dynamic population of stromal cells contributes to the follicle stem cell niche in the Drosophila ovary. Development 140:4490-8
Sahai-Hernandez, Pankaj; Castanieto, Angela; Nystul, Todd G (2012) Drosophila models of epithelial stem cells and their niches. Wiley Interdiscip Rev Dev Biol 1:447-57