This proposal is directed toward the elucidation of the molecular and biologic functions of the PR and a key steroid receptor coactivator (SRC-1). The investigator proposes to generate mouse models in which the normal pattern of SRC-1 gene expression is disrupted in order to provide unequivocal evidence of in vivo coactivator function.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD007857-29
Application #
6182165
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Yoshinaga, Koji
Project Start
1977-05-01
Project End
2002-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
29
Fiscal Year
2000
Total Cost
$437,117
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Panigrahi, Anil K; Foulds, Charles E; Lanz, Rainer B et al. (2018) SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell 70:679-694.e7
Szwarc, Maria M; Hai, Lan; Gibbons, William E et al. (2018) Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics Reproduction 156:387-395
Dasgupta, Subhamoy; Rajapakshe, Kimal; Zhu, Bokai et al. (2018) Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature 556:249-254
Szwarc, Maria M; Kommagani, Ramakrishna; Putluri, Vasanta et al. (2018) Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep 8:13134
Gates, Leah A; Gu, Guowei; Chen, Yue et al. (2018) Proteomic profiling identifies key coactivators utilized by mutant ER? proteins as potential new therapeutic targets. Oncogene 37:4581-4598
Rohira, Aarti D; Yan, Fei; Wang, Lei et al. (2017) Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res 77:4293-4304
Zhu, Bokai; Zhang, Qiang; Pan, Yinghong et al. (2017) A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms. Cell Metab 25:1305-1319.e9
Han, Sang Jun; Begum, Khurshida; Foulds, Charles E et al. (2016) The Dual Estrogen Receptor ? Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol 89:14-26
Szwarc, Maria M; Lydon, John P; O'Malley, Bert W (2015) Steroid receptor coactivators as therapeutic targets in the female reproductive system. J Steroid Biochem Mol Biol 154:32-8
Zhu, Bokai; Gates, Leah A; Stashi, Erin et al. (2015) Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading. Mol Cell 60:769-783

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