Three specific aims are listed: (1) to identify the mechanisms by which adherens junctions are assembled in the early embryo; (2) to elucidate the mechanisms by which adherens junctions are disassembled during epithelial-mesenchymal transitions; and (3) to determine the mechanisms by which cell/matrix adhesion is altered at the epithelial-mesenchymal transition.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD014483-19
Application #
2673452
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1980-07-01
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
19
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Duke University
Department
Zoology
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Slota, Leslie A; McClay, David R (2018) Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo. Dev Biol 435:138-149
McClay, David R; Miranda, Esther; Feinberg, Stacy L (2018) Neurogenesis in the sea urchin embryo is initiated uniquely in three domains. Development 145:
Martik, Megan L; McClay, David R (2017) New insights from a high-resolution look at gastrulation in the sea urchin, Lytechinus variegatus. Mech Dev 148:3-10
Martik, Megan L; Lyons, Deirdre C; McClay, David R (2016) Developmental gene regulatory networks in sea urchins and what we can learn from them. F1000Res 5:
Warner, Jacob F; Miranda, Esther L; McClay, David R (2016) Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin. Dev Biol 411:314-324
Israel, Jennifer W; Martik, Megan L; Byrne, Maria et al. (2016) Comparative Developmental Transcriptomics Reveals Rewiring of a Highly Conserved Gene Regulatory Network during a Major Life History Switch in the Sea Urchin Genus Heliocidaris. PLoS Biol 14:e1002391
Martik, Megan L; McClay, David R (2015) Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo. Elife 4:
Warner, Jacob F; McClay, David R (2014) Perturbations to the hedgehog pathway in sea urchin embryos. Methods Mol Biol 1128:211-21
Lyons, Deirdre C; Martik, Megan L; Saunders, Lindsay R et al. (2014) Specification to biomineralization: following a single cell type as it constructs a skeleton. Integr Comp Biol 54:723-33
Cheng, Xianrui; Lyons, Deirdre C; Socolar, Joshua E S et al. (2014) Delayed transition to new cell fates during cellular reprogramming. Dev Biol 391:147-57

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