of the proposed activity suitable for dissemination to the public. It should be a self-contained description of the project and should contain a statement of objectives and methods to be employed. It should be informative to other persons working in the same or related fields and insofar as possible understandable to a scientifically or technically literate lay reader. This abstract must not include any proprietary or confidential information. This section must be no longer than 30 lines of text. 2.

Public Health Relevance

Many human diseases are the result of incorrect interpretation of genome sequence due to abnormalities in the structure of chromatin that packages DNA in the nucleus. Studies on chromatin remodeling proteins and non-coding RNAs have demonstrated their ability to disrupt histone-DNA contacts and reposition nucleosomes. Consequently, these complexes are critical in regulating global gene expression. Genetic experiments that elucidate the biological specificity of these proteins and non-coding RNAs, along with the abnormal outcomes associated with disease states when inappropriately expressed, will be beneficial to studies related to human health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD024462-23
Application #
7923969
Study Section
Development - 2 Study Section (DEV2)
Program Officer
Mukhopadhyay, Mahua
Project Start
1989-12-01
Project End
2012-04-14
Budget Start
2010-09-01
Budget End
2012-04-14
Support Year
23
Fiscal Year
2010
Total Cost
$510,758
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Genetics
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Richie, Ellen R; Schumacher, Armin; Angel, Joe M et al. (2002) The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas. Oncogene 21:299-306
Morin-Kensicki, E M; Faust, C; LaMantia, C et al. (2001) Cell and tissue requirements for the gene eed during mouse gastrulation and organogenesis. Genesis 31:142-6
Lessard, J; Schumacher, A; Thorsteinsdottir, U et al. (1999) Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev 13:2691-703
Faust, C; Lawson, K A; Schork, N J et al. (1998) The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development 125:4495-506
van Lohuizen, M; Tijms, M; Voncken, J W et al. (1998) Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. Mol Cell Biol 18:3572-9
Schumacher, A; Lichtarge, O; Schwartz, S et al. (1998) The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation. Genomics 54:79-88
Holdener, B C; Brown, S D; Angel, J M et al. (1993) Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 7. Mamm Genome 4 Spec No:S110-20
Faust, C; Magnuson, T (1993) Genetic control of gastrulation in the mouse. Curr Opin Genet Dev 3:491-8
Williams, P T; Krauss, R M; Vranizan, K M et al. (1992) Associations of lipoproteins and apolipoproteins with gradient gel electrophoresis estimates of high density lipoprotein subfractions in men and women. Arterioscler Thromb 12:332-40
Kelsey, G; Schedl, A; Ruppert, S et al. (1992) Physical mapping of the albino-deletion complex in the mouse to localize alf/hsdr-1, a locus required for neonatal survival. Genomics 14:275-87

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