This proposal addresses the role of Nuclear Factor-I (NF-I) in animal development.
The specific aims are: 1) to address the roles of NFI-A and -C, targeted disruption of these gene will be made and the phenotypes of the resulting mice analyzed; 2) to use C. elegans to study the role of the single NF-I gene by disrupting this gene and assessing developmental defects.
|Muthusamy, Natarajan; Chen, Hui-Chen; Rajgolikar, Girish et al. (2011) Recombination activation gene-2-deficient blastocyst complementation analysis reveals an essential role for nuclear factor I-A transcription factor in T-cell activation. Int Immunol 23:385-90|
|Lazakovitch, Elena; Kalb, John M; Matsumoto, Reiko et al. (2005) nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival. BMC Dev Biol 5:24|
|Steele-Perkins, George; Plachez, Celine; Butz, Kenneth G et al. (2005) The transcription factor gene Nfib is essential for both lung maturation and brain development. Mol Cell Biol 25:685-98|
|Ling, Guoyu; Hauer, Charles R; Gronostajski, Richard M et al. (2004) Transcriptional regulation of rat CYP2A3 by nuclear factor 1: identification of a novel NFI-A isoform, and evidence for tissue-selective interaction of NFI with the CYP2A3 promoter in vivo. J Biol Chem 279:27888-95|
|Messam, Conrad A; Hou, Jean; Gronostajski, Richard M et al. (2003) Lineage pathway of human brain progenitor cells identified by JC virus susceptibility. Ann Neurol 53:636-46|
|Pan, Li; Glenn, Sean T; Jones, Craig A et al. (2003) Regulation of renin enhancer activity by nuclear factor I and Sp1/Sp3. Biochim Biophys Acta 1625:280-90|
|Bachurski, Cindy J; Yang, Guan Hu; Currier, Tracey A et al. (2003) Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. Mol Cell Biol 23:9014-24|
|Murtagh, Janice; Martin, Finian; Gronostajski, Richard M (2003) The Nuclear Factor I (NFI) gene family in mammary gland development and function. J Mammary Gland Biol Neoplasia 8:241-54|
|Shu, Tianzhi; Butz, Kenneth G; Plachez, Celine et al. (2003) Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out mice. J Neurosci 23:203-12|
|Majumder, S; Ghoshal, K; Gronostajski, R M et al. (2001) Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I. Gene Expr 9:203-15|
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