Cerebellar damage can be caused by tumor, stroke, hemorrhage, or degenerative disease. Ataxia resulting from cerebellar damage is extremely difficult to treat; most interventions include physical therapy. Our long range goal is to help elucidate the mechanisms by which cerebellar damage alters the production of normal movement and provide information that will enhance rehabilitation treatments for ataxia. The proposed studies will test the general hypothesis that the cerebellum adjusts the relative movements between joints and limbs through trial-and-error practice, making movements automatic and efficient. We believe that deficits in automaticity and efficiency combine to make movements far more mentally and physically taxing, leading to a decline in general activity level and function. Experiments will address: (1) whether people with cerebellar damage show degradation of movement automaticity, (2) whether people with gait ataxia show relative scaling deficits of joints within a leg because of an inability to adjust for interaction torques, and (3) whether cerebellar damage interferes with learning to adjust the scaling between legs during walking. To address these aims, kinematic, kinetic, and electromyographic data will be collected from people with cerebellar damage and control subjects as they perform a variety of movements used in everyday function (e.g. walking, stepping over obstacles and reaching while standing). The proposed experiments are designed to more clearly define the nature of impairments caused by cerebellar damage and provide a basis for interventions that can improve the functional limitations of people with cerebellar damage.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD040289-03
Application #
6722916
Study Section
Geriatrics and Rehabilitation Medicine (GRM)
Program Officer
Nitkin, Ralph M
Project Start
2002-02-18
Project End
2006-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
3
Fiscal Year
2004
Total Cost
$229,455
Indirect Cost
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Therrien, Amanda S; Wolpert, Daniel M; Bastian, Amy J (2018) Increasing Motor Noise Impairs Reinforcement Learning in Healthy Individuals. eNeuro 5:
Statton, Matthew A; Vazquez, Alejandro; Morton, Susanne M et al. (2018) Making Sense of Cerebellar Contributions to Perceptual and Motor Adaptation. Cerebellum 17:111-121
Zimmet, Amanda M; Cowan, Noah J; Bastian, Amy J (2018) Patients with Cerebellar Ataxia Do Not Benefit from Limb Weights. Cerebellum :
Weeks, Heidi M; Therrien, Amanda S; Bastian, Amy J (2017) Proprioceptive Localization Deficits in People With Cerebellar Damage. Cerebellum 16:427-437
Weeks, Heidi M; Therrien, Amanda S; Bastian, Amy J (2017) The cerebellum contributes to proprioception during motion. J Neurophysiol 118:693-702
Therrien, Amanda S; Wolpert, Daniel M; Bastian, Amy J (2016) Effective reinforcement learning following cerebellar damage requires a balance between exploration and motor noise. Brain 139:101-14
Vazquez, Alejandro; Statton, Matthew A; Busgang, Stefanie A et al. (2015) Split-belt walking adaptation recalibrates sensorimotor estimates of leg speed but not position or force. J Neurophysiol 114:3255-67
Statton, Matthew A; Encarnacion, Marysol; Celnik, Pablo et al. (2015) A Single Bout of Moderate Aerobic Exercise Improves Motor Skill Acquisition. PLoS One 10:e0141393
Therrien, Amanda S; Bastian, Amy J (2015) Cerebellar damage impairs internal predictions for sensory and motor function. Curr Opin Neurobiol 33:127-33
Musselman, Kristin E; Stoyanov, Cristina T; Marasigan, Rhul et al. (2014) Prevalence of ataxia in children: a systematic review. Neurology 82:80-9

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