The long-term goal of this project is to provide new methods for statistical linkage analysis of linkage data in gene mapping for complex traits. Results are expected to increase reliability and power of analysis methods. On an on-going basis, up-to-date versions of linkage programs and information of general interest to statistical geneticists is freely made available through a home page on the world wide web. Also, on-going is the publication of a Linkage Newsletter although it is being phased out.
The specific aims focus on methods of development for linkage and disequilibrium analysis based on case-control or nuclear families. Single-locus test statistics, summed over multiple markers in the vicinity of disease genes, are expected to be particularly powerful for complex traits (aim 1). Log linear modeling may be applied to multiple linked or unlinked markers and is expected to be a useful tool for modeling interactions between loci. Finally, users will continue to receive rapid and reliable support.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project (R01)
Project #
2R01HG000008-12
Application #
6262666
Study Section
Mammalian Genetics Study Section (MGN)
Program Officer
Brooks, Lisa
Project Start
1990-03-01
Project End
2005-02-28
Budget Start
2001-03-01
Budget End
2002-02-28
Support Year
12
Fiscal Year
2001
Total Cost
$243,800
Indirect Cost
Name
Rockefeller University
Department
Biostatistics & Other Math Sci
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Ulgen, Ayse; Yoo, Yun Joo; Gordon, Derek et al. (2004) Percentiles of the null distribution of 2 maximum lod score tests. Hum Hered 57:39-48
Hoh, Josephine; Matsuda, Fumihiko; Peng, Xu et al. (2003) SNP haplotype tagging from DNA pools of two individuals. BMC Bioinformatics 4:14
Ott, Jurg; Hoh, Josephine (2003) Set association analysis of SNP case-control and microarray data. J Comput Biol 10:569-74
Wessman, Maija; Kallela, Mikko; Kaunisto, Mari A et al. (2002) A susceptibility locus for migraine with aura, on chromosome 4q24. Am J Hum Genet 70:652-62
Hoh, J; Jin, S; Parrado, T et al. (2002) The p53MH algorithm and its application in detecting p53-responsive genes. Proc Natl Acad Sci U S A 99:8467-72
Li, W; Fann, C S; Ott, J (1998) Low-order polynomial trends of female-to-male map distance ratios along human chromosomes. Hum Hered 48:266-70
Klein, M L; Schultz, D W; Edwards, A et al. (1998) Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. Arch Ophthalmol 116:1082-8
Brzustowicz, L M; Kleyn, P W; Boyce, F M et al. (1992) Fine-mapping of the spinal muscular atrophy locus to a region flanked by MAP1B and D5S6. Genomics 13:991-8