Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL038622-11
Application #
2218951
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-09-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Zhang, Jin; Vanhaesebroeck, Bart; Rittenhouse, Susan E (2002) Human platelets contain p110delta phosphoinositide 3-kinase. Biochem Biophys Res Commun 296:178-81
Jin, Jianguo; Quinton, Todd M; Zhang, Jin et al. (2002) Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors. Blood 99:193-8
Banfic, H; Tang, X; Batty, I H et al. (1998) A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets. J Biol Chem 273:13-6
Zhang, J; Banfic, H; Straforini, F et al. (1998) A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. J Biol Chem 273:14081-4
Banfic, H; Downes, C P; Rittenhouse, S E (1998) Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:11630-7
Domin, J; Pages, F; Volinia, S et al. (1997) Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J 326 ( Pt 1):139-47
Abrams, C S; Zhang, J; Downes, C P et al. (1996) Phosphopleckstrin inhibits gbetagamma-activable platelet phosphatidylinositol-4,5-bisphosphate 3-kinase. J Biol Chem 271:25192-7
Zhang, J; Zhang, J; Shattil, S J et al. (1996) Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin. J Biol Chem 271:6265-72
Rittenhouse, S E (1996) Phosphoinositide 3-kinase activation and platelet function. Blood 88:4401-14
Zhang, J; Falck, J R; Reddy, K K et al. (1995) Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets. J Biol Chem 270:22807-10

Showing the most recent 10 out of 34 publications