The proposal is a competitive continuation of an original grant that has led to the clinical application of inhaled nitric oxide (NO) for the treatment of pulmonary hypertension. Inhaled NO will produce selective pulmonary vasodilation IN VENTILATED alveoli in some 60% of individuals without causing a fall in arterial oxygen saturation. However, 40% of patients do noT responD to NO. The investigators will study the roles of oxygen radicals and eicosanoids in hyporesponsiveness to NO. They will determine the relationship of loss of responsiveness to NO and the loss of hypoxic pulmonary vasoconstriction (HPV) in sepsis, especially as it may relate to inducible No synthase. Lastly, they will study inhalation therapy with agents that do not affect HPV and see if they are effective in enhancing gas exchange in ovine and murine lung injury models.
| Vaporidi, Katerina; Vergadi, Eleni; Kaniaris, Evangelos et al. (2012) Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 303:L199-207 |
| Steinbicker, Andrea U; Liu, Heling; Jiramongkolchai, Kim et al. (2011) Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Nitric Oxide 25:294-302 |
| Petersen, Bodil; Austen, K Frank; Bloch, Kenneth D et al. (2011) Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology 115:804-11 |
| Yu, Binglan; Shahid, Mohd; Egorina, Elena M et al. (2010) Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology 112:586-94 |
| Vaporidi, Katerina; Francis, Roland C; Bloch, Kenneth D et al. (2010) Nitric oxide synthase 3 contributes to ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 299:L150-9 |
| Buys, Emmanuel S; Cauwels, Anje; Raher, Michael J et al. (2009) sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol 297:H654-63 |
| Yu, Binglan; Volpato, Gian Paolo; Chang, Keqin et al. (2009) Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology 110:113-22 |
| Yu, Binglan; Bloch, Kenneth D; Zapol, Warren M (2009) Hemoglobin-based red blood cell substitutes and nitric oxide. Trends Cardiovasc Med 19:103-7 |
| Petersen, Bodil; Bloch, Kenneth D; Ichinose, Fumito et al. (2008) Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Am J Physiol Lung Cell Mol Physiol 294:L300-8 |
| Yu, Binglan; Raher, Michael J; Volpato, Gian Paolo et al. (2008) Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation 117:1982-90 |
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