Heart disease, a major cause of morbidity and mortality in the Western World, generally leads to abnormalities of heart wall motion. The goals of this project are 1) to develop improved methods for measuring regional heart wall motion using magnetic resonance imaging (MRI); and 2) to apply them to a sample of normal subjects in order to define the normal patterns of cardiac motion. This will be useful both for improving our understanding of normal cardiac motion and for providing a set of baseline normal values against which patients with heart disease can be compared. In addition, improved methods for cardiac imaging with MRI that will be developed for this project will have broader applicability to general cardiac MRI. A major focus of this project is on development of technical aspects of the wall motion studies. Methods will be developed for the acquisition of tagged MR cardiac images with improved spatial and temporal resolution, including investigations of tagged imaging during suspended respiration with rapid gradient echo and echo planar imaging and development of surface coils specifically adapted for receiving signals from the heart. Analysis methods will be developed for estimating the 3-dimensional motion and deformation from both stacked biplane series and phase velocity encoding. Validation methods for verification of measurement results will be further developed. Image registration methods will be developed for studies of reproducibility and comparison of different subjects. The improved imaging and analysis methods developed in this project will be applied to a broad sample of normal subjects, stratified for gender, age and race. This will be analyzed for within and between subject patterns of variation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL043014-07A1
Application #
2028473
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1990-04-01
Project End
1999-12-31
Budget Start
1997-01-01
Budget End
1997-12-31
Support Year
7
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Axel, Leon; Montillo, Albert; Kim, Daniel (2005) Tagged magnetic resonance imaging of the heart: a survey. Med Image Anal 9:376-93
Moses, Daniel A; Axel, Leon (2004) Quantification of the curvature and shape of the interventricular septum. Magn Reson Med 52:154-63
Yeon, S B; Reichek, N; Tallant, B A et al. (2001) Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry. J Am Coll Cardiol 38:555-61
Yuan, Q; Axel, L; Hernandez, E H et al. (2000) Cardiac-respiratory gating method for magnetic resonance imaging of the heart. Magn Reson Med 43:314-8
Haber, I; Metaxas, D N; Axel, L (2000) Three-dimensional motion reconstruction and analysis of the right ventricle using tagged MRI. Med Image Anal 4:335-55
Fayad, Z A; Ferrari, V A; Kraitchman, D L et al. (1998) Right ventricular regional function using MR tagging: normals versus chronic pulmonary hypertension. Magn Reson Med 39:116-23
Kraitchman, D L; Young, A A; Bloomgarden, D C et al. (1998) Integrated MRI assessment of regional function and perfusion in canine myocardial infarction. Magn Reson Med 40:311-26
Axel, L (1997) Noninvasive measurement of cardiac strain with MRI. Adv Exp Med Biol 430:249-56
Gai, N; Axel, L (1997) A dual approach to linogram imaging for MRI. Magn Reson Med 38:337-41
Bloomgarden, D C; Fayad, Z A; Ferrari, V A et al. (1997) Global cardiac function using fast breath-hold MRI: validation of new acquisition and analysis techniques. Magn Reson Med 37:683-92

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