Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL048008-05
Application #
2224048
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1991-09-09
Project End
2000-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Taulet, Nicolas; Delorme-Walker, Violaine D; DerMardirossian, Celine (2012) Reactive oxygen species regulate protrusion efficiency by controlling actin dynamics. PLoS One 7:e41342
Gianni, Davide; DerMardirossian, Céline; Bokoch, Gary M (2011) Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. Eur J Cell Biol 90:164-71
Gianni, Davide; Taulet, Nicolas; DerMardirossian, Celine et al. (2010) c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells. Mol Biol Cell 21:4287-98
Gianni, Davide; Taulet, Nicolas; Zhang, Hui et al. (2010) A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem Biol 5:981-93
Kim, Jun-Sub; Bokoch, Gary M (2009) Anthrax edema toxin inhibits Nox1-mediated formation of reactive oxygen species by colon epithelial cells. J Innate Immun 1:145-52
Bokoch, Gary M; Diebold, Becky; Kim, Jun-Sub et al. (2009) Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases. Antioxid Redox Signal 11:2429-41
Bielek, Heike; Anselmo, Anthony; Dermardirossian, Celine (2009) Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI. Cell Signal 21:1974-83
Gianni, Davide; Diaz, Begoña; Taulet, Nicolas et al. (2009) Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal 2:ra54
Kim, Jun-Sub; Huang, Timothy Y; Bokoch, Gary M (2009) Reactive oxygen species regulate a slingshot-cofilin activation pathway. Mol Biol Cell 20:2650-60
Roepstorff, Kirstine; Rasmussen, Izabela; Sawada, Makoto et al. (2008) Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis. J Biol Chem 283:7983-93

Showing the most recent 10 out of 48 publications