Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052461-03
Application #
2229838
Study Section
Special Emphasis Panel (CM)
Project Start
1993-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146

  Publications

Mammolenti, Michele; Gajavelli, Shyam; Tsoulfas, Pantelis et al. (2004) Absence of major histocompatibility complex class I on neural stem cells does not permit natural killer cell killing and prevents recognition by alloreactive cytotoxic T lymphocytes in vitro. Stem Cells 22:1101-10
Komatsu, Masanobu; Mammolenti, Michele; Jones, Monica et al. (2003) Antigen-primed CD8+ T cells can mediate resistance, preventing allogeneic marrow engraftment in the simultaneous absence of perforin-, CD95L-, TNFR1-, and TRAIL-dependent killing. Blood 101:3991-9
Yu, Aixin; Zhou, Jiehao; Marten, Norman et al. (2003) Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors. J Immunol 170:236-42
Jiang, Zhe; Adams, Gregor B; Hanash, Alan M et al. (2002) The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 8:588-96
Jiang, Z; Podack, E; Levy, R B (2001) Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenes Blood 98:390-7
Jones, M; Komatsu, M; Levy, R B (2000) Cytotoxically impaired transplant recipients can efficiently resist major histocompatibility complex--matched bone marrow allografts. Biol Blood Marrow Transplant 6:456-64
Levy, R B; Jones, M; Hamilton, B L et al. (1995) IL-7 drives donor T cell proliferation and can costimulate cytokine secretion after MHC-matched allogeneic bone marrow transplantation. J Immunol 154:106-15