Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL053514-01A2
Application #
2029275
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-09-30
Project End
2000-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
Longhurst, Celia M; Jacobs, Jonathan D; White, Melanie M et al. (2002) Chinese hamster ovary cell motility to fibronectin is modulated by the second extracellular loop of CD9. Identification of a putative fibronectin binding site. J Biol Chem 277:32445-52
Cook, George A; Longhurst, Celia M; Grgurevich, Svetozar et al. (2002) Identification of CD9 extracellular domains important in regulation of CHO cell adhesion to fibronectin and fibronectin pericellular matrix assembly. Blood 100:4502-11
Mondoro, T H; White, M M; Jennings, L K (2000) Active GPIIb-IIIa conformations that link ligand interaction with cytoskeletal reorganization. Blood 96:2487-95
Jennings, L K; Haga, J H; Slack, S M (2000) Differential expression of a ligand induced binding site (LIBS) by GPIIb-IIIa ligand recognition peptides and parenteral antagonists. Thromb Haemost 84:1095-102
Cook, G A; Wilkinson, D A; Crossno Jr, J T et al. (1999) The tetraspanin CD9 influences the adhesion, spreading, and pericellular fibronectin matrix assembly of Chinese hamster ovary cells on human plasma fibronectin. Exp Cell Res 251:356-71
Longhurst, C M; White, M M; Wilkinson, D A et al. (1999) A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. Eur J Biochem 263:104-11
Jackson, D E; White, M M; Jennings, L K et al. (1998) A Ser162-->Leu mutation within glycoprotein (GP) IIIa (integrin beta3) results in an unstable alphaIIbbeta3 complex that retains partial function in a novel form of type II Glanzmann thrombasthenia. Thromb Haemost 80:42-8
Longhurst, C M; Jennings, L K (1998) Integrin-mediated signal transduction. Cell Mol Life Sci 54:514-26