The present project represents the first high-risk study of Attention Deficit Hyperactivity Disorder (ADHD). Its overall aim is to advance our understanding of the familial pattern of ADHD, using a high-risk design that examines risks conferred to offspring of individuals who had ADHD in childhood. Specifically, we will examine in children at high and low risk for ADHD: (1) differential social, behavioral, cognitive, and diagnostic characteristics, and; (2) differential risk factors, including familial features and parental psychopathology. The findings of this study will provide information critical to the identification of vulnerable and at risk children and will contribute to the rational design of preventive approaches.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
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Child Psychopathology and Treatment Review Committee (CPT)
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Long Island Jewish Medical Center
New Hyde Park
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Cortese, Samuele; Imperati, Davide; Zhou, Juan et al. (2013) White matter alterations at 33-year follow-up in adults with childhood attention-deficit/hyperactivity disorder. Biol Psychiatry 74:591-8
Ramos Olazagasti, Maria A; Klein, Rachel G; Mannuzza, Salvatore et al. (2013) Does childhood attention-deficit/hyperactivity disorder predict risk-taking and medical illnesses in adulthood? J Am Acad Child Adolesc Psychiatry 52:153-162.e4
Cortese, Samuele; Ramos Olazagasti, Maria A; Klein, Rachel G et al. (2013) Obesity in men with childhood ADHD: a 33-year controlled, prospective, follow-up study. Pediatrics 131:e1731-8
Mannuzza, Salvatore; Castellanos, Francisco X; Roizen, Erica R et al. (2011) Impact of the impairment criterion in the diagnosis of adult ADHD: 33-year follow-up study of boys with ADHD. J Atten Disord 15:122-9
Mannuzza, Salvatore; Klein, Rachel G; Moulton 3rd, John L (2008) Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatry Res 160:237-46
Mannuzza, Salvatore; Klein, Rachel G; Truong, Nhan L et al. (2008) Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. Am J Psychiatry 165:604-9
Mannuzza, S; Klein, R G; Bessler, A et al. (1993) Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry 50:565-76
Klein, R G; Mannuzza, S (1991) Long-term outcome of hyperactive children: a review. J Am Acad Child Adolesc Psychiatry 30:383-7
Mannuzza, S; Klein, R G; Addalli, K A (1991) Young adult mental status of hyperactive boys and their brothers: a prospective follow-up study. J Am Acad Child Adolesc Psychiatry 30:743-51
Mannuzza, S; Klein, R G; Bonagura, N et al. (1991) Hyperactive boys almost grown up. V. Replication of psychiatric status. Arch Gen Psychiatry 48:77-83

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