This application is a competitive renewal of a longitudinal study of infants at risk for autism (R01 MH068398, 7/1/03 - 6/30/08). In the first five years of funding, a cross-site study (UC Davis and UCLA) was conducted in which 180 siblings of children with autism were compared to 90 siblings of children with typical development on a wide array of behavioral tasks measuring constructs important to the very early autism phenotype. In this competitive renewal, we request additional funds to recruit a new sample of infant siblings and to follow longitudinally the original sample as they enter school. Based on our previous findings of few differences in behavioral symptoms at 6 and 12 months of age, experimental measures used with the new sample will focus on underlying processes that may reveal differences in at-risk children prior to the onset of behavioral signs of disorder. Collaboration with UCLA will continue for both the new sample and the longitudinal follow-up of the previous sample.
Specific aims are to:
AIM 1 : Identify reliable markers that differentiate children with autism or ASD outcomes from children with other or no developmental delays, examining both onset of symptoms and potential underlying mechanisms to see when trajectories diverge and in what domains (Study 1: newly ascertained infant sibling sample).
AIM 2 : In the sample of siblings of children with autism recruited in the prior award period, examine stability of autism and PDDNOS diagnoses and identify later-appearing developmental problems by assessing functioning at age 6 (Study 2: longitudinal follow up of previous infant sibling sample).

Public Health Relevance

DESCRIPTION The long-term goal of this research is to understand the earliest features of autism, leading to the design of better screening and identification tools. In study 1, infant siblings of children with autism will be enrolled in the study before their first birthday and then followed until age 3, through the window of risk for autism development, to see how early the disorder can be identified and differentiated from other types of developmental delays. In study 2, the sample of infant siblings recruited in the prior award period will be followed as they begin school (age 6) to examine the stability of autism diagnoses and identify later-appearing developmental problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH068398-10
Application #
8384850
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Gilotty, Lisa
Project Start
2009-01-01
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2014-11-30
Support Year
10
Fiscal Year
2013
Total Cost
$551,100
Indirect Cost
$191,227
Name
University of California Davis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Schwichtenberg, A J; Kellerman, Ashleigh M; Young, Gregory S et al. (2018) Mothers of children with autism spectrum disorders: Play behaviors with infant siblings and social responsiveness. Autism :1362361318782220
Miller, Meghan; Iosif, Ana-Maria; Young, Gregory S et al. (2018) The dysregulation profile in preschoolers with and without a family history of autism spectrum disorder. J Child Psychol Psychiatry :
Miller, Meghan; Iosif, Ana-Maria; Young, Gregory S et al. (2018) Early Detection of ADHD: Insights From Infant Siblings of Children With Autism. J Clin Child Adolesc Psychol 47:737-744
Gangi, Devon N; Schwichtenberg, A J; Iosif, Ana-Maria et al. (2018) Gaze to faces across interactive contexts in infants at heightened risk for autism. Autism 22:763-768
Ozonoff, Sally; Gangi, Devon; Hanzel, Elise P et al. (2018) Onset patterns in autism: Variation across informants, methods, and timing. Autism Res 11:788-797
Ozonoff, Sally; Young, Gregory S; Brian, Jessica et al. (2018) Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy. J Am Acad Child Adolesc Psychiatry 57:849-857.e2
Miller, Meghan; Iosif, Ana-Maria; Hill, Monique et al. (2017) Response to Name in Infants Developing Autism Spectrum Disorder: A Prospective Study. J Pediatr 183:141-146.e1
Charman, Tony; Young, Gregory S; Brian, Jessica et al. (2017) Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Res 10:169-178
Messinger, Daniel S; Young, Gregory S; Webb, Sara Jane et al. (2016) Commentary: sex difference differences? A reply to Constantino. Mol Autism 7:31
Miller, Meghan; Iosif, Ana-Maria; Young, Gregory S et al. (2016) School-age outcomes of infants at risk for autism spectrum disorder. Autism Res 9:632-42

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