Internal Sensing Systems in Hypothalamus

Hatton, Glenn I.

Abstract

The work proposed here will investigate the roles played in the osmodetection process by the neurons and glial cells in and around three magnocellular nuclei paraventricular and supraoptic nuclei and the nucleus circularis all of the hypothalamus. In addition, osmosensitive cells, in other nearby locations, that may be presynaptic to the neurons of the three magnocellular nuclei will be investigated. The approaches to be used in these studies include light and electron microscopy, electrophysiology of brain slices and immunocytochemistry.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS009140-20
• Application #: 3393912
• Study Section: Biopsychology Study Section (BPO)
• Project Start: 1977-01-01
• Project End: 1992-12-31
• Budget Start: 1990-01-01
• Budget End: 1990-12-31
• Support Year: 20
• Fiscal Year: 1990

Institution

• Name: Michigan State University
• Type: Schools of Arts and Sciences
• DUNS #: 193247145
• City: East Lansing
• State: MI
• Country: United States
• Zip Code: 48824

Publications

Wang, Ping; Qin, Danian; Wang, Yu-Feng (2017) Oxytocin Rapidly Changes Astrocytic GFAP Plasticity by Differentially Modulating the Expressions of pERK 1/2 and Protein Kinase A. Front Mol Neurosci 10:262

Hatton, Glenn I; Yang, Qin Zhao (2002) Synaptic potentials mediated by alpha 7 nicotinic acetylcholine receptors in supraoptic nucleus. J Neurosci 22:29-37

Hatton, G I; Yang, Q Z (2001) Ionotropic histamine receptors and H2 receptors modulate supraoptic oxytocin neuronal excitability and dye coupling. J Neurosci 21:2974-82

Yang, Q Z; Hatton, G I (1999) Nitric oxide via cGMP-dependent mechanisms increases dye coupling and excitability of rat supraoptic nucleus neurons. J Neurosci 19:4270-9

Yang, Q Z; Hatton, G I (1997) Electrophysiology of excitatory and inhibitory afferents to rat histaminergic tuberomammillary nucleus neurons from hypothalamic and forebrain sites. Brain Res 773:162-72

Hatton, G I; Yang, Q Z (1996) Synaptically released histamine increases dye coupling among vasopressinergic neurons of the supraoptic nucleus: mediation by H1 receptors and cyclic nucleotides. J Neurosci 16:123-9