Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020591-09
Application #
3401034
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1984-04-01
Project End
1992-04-30
Budget Start
1991-12-01
Budget End
1992-04-30
Support Year
9
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Eunice Kennedy Shriver Center Mtl Retardatn
Department
Type
DUNS #
City
Waltham
State
MA
Country
United States
Zip Code
02254
Jiang, Dewei; Zhang, Ying; Hart, Ronald P et al. (2015) Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain 138:3520-36
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Chow, Hei-Man; Guo, Dong; Zhou, Jie-Chao et al. (2014) CDK5 activator protein p25 preferentially binds and activates GSK3?. Proc Natl Acad Sci U S A 111:E4887-95
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Chen, Jianmin; Herrup, Karl (2012) Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress. PLoS One 7:e33177
Zhang, Jie; Li, Huifang; Zhou, Tingwen et al. (2012) Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. J Biol Chem 287:25985-94
Li, Jiali; Chen, Jianmin; Ricupero, Christopher L et al. (2012) Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nat Med 18:783-90
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Zhang, Jie; Li, Huifang; Herrup, Karl (2010) Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation. J Biol Chem 285:14052-61

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