Abstract

How are individual peripheral visceral organs controlled by the brain? Katz and Karten [49-56] have demonstrated the existence of a precise organotopic representation of the peripheral visceral organs in subnuclei of the nuc. tractus solitarius and the motor nucleus of the vagus (nTs-DMX). What are the central afferent and efferent connections of each organ specific subnucleus of nTs and DMX? Are there separate anatomical lemnisci for regulation of pulmonary, GI, pancreatic and cardoivascular systems between nTs-DMX and other regions of the brain, such as the hypothalamus? The differential afferent and efferent central connections of organ specific subnuclei of the nTs-DMX will be studied using histological methods, including ARG nTs-DMX is veritable storehouse of various peptides/transmitters of both extrinsic and intrinsic origin. Including SP, CCK, ENK, VIP, NT, DA, NE, 5-HT, GAD/Gaba and subsets CAT. Pilot studies have revealed their differential distribution in organ specific of the nTs-DMX. The origin, localization and ontogeny of these immunohistochemically distinct inputs will be investigated. These experiments will help clarify the potential mechanisms of neuronal regulation of individual viscera by the hypothalamus and the boichemical and pharmacological organization of nTs-DMX.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS024560-01
Application #
3409289
Study Section
Neurology A Study Section (NEUA)
Project Start
1986-07-01
Project End
1988-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Vega-Zuniga, Tomas; Mpodozis, Jorge; Karten, Harvey J et al. (2014) Morphology, projection pattern, and neurochemical identity of Cajal's ""centrifugal neurons"": the cells of origin of the tectoventrogeniculate pathway in pigeon (Columba livia) and chicken (Gallus gallus). J Comp Neurol 522:2377-96
Fredes, Felipe; Vega-Zuniga, Tomas; Karten, Harvey et al. (2012) Bilateral and ipsilateral ascending tectopulvinar pathways in mammals: a study in the squirrel (Spermophilus beecheyi). J Comp Neurol 520:1800-18
Wang, Yuan; Brzozowska-Prechtl, Agnieszka; Karten, Harvey J (2010) Laminar and columnar auditory cortex in avian brain. Proc Natl Acad Sci U S A 107:12676-81
Wang, Yuan; Karten, Harvey J (2010) Three subdivisions of the auditory midbrain in chicks (Gallus gallus) identified by their afferent and commissural projections. J Comp Neurol 518:1199-219
Wang, Yuan; Luksch, Harald; Brecha, Nicholas C et al. (2006) Columnar projections from the cholinergic nucleus isthmi to the optic tectum in chicks (Gallus gallus): a possible substrate for synchronizing tectal channels. J Comp Neurol 494:7-35
Wang, Yuan; Major, Daniel E; Karten, Harvey J (2004) Morphology and connections of nucleus isthmi pars magnocellularis in chicks (Gallus gallus). J Comp Neurol 469:275-97
Marin, Gonzalo; Letelier, Juan Carlos; Henny, Pablo et al. (2003) Spatial organization of the pigeon tectorotundal pathway: an interdigitating topographic arrangement. J Comp Neurol 458:361-80
Major, Daniel E; Rodman, Hillary R; Libedinsky, Camilo et al. (2003) Pattern of retinal projections in the California ground squirrel (Spermophilus beecheyi): anterograde tracing study using cholera toxin. J Comp Neurol 463:317-40
Wu, C C; Russell, R M; Nguyen, R T et al. (2003) Tracing developing pathways in the brain: a comparison of carbocyanine dyes and cholera toxin b subunit. Neuroscience 117:831-45
Wu, C C; Russell, R M; Karten, H J (2000) Ontogeny of the tectorotundal pathway in chicks (Gallus gallus): birthdating and pathway tracing study. J Comp Neurol 417:115-32

Showing the most recent 10 out of 36 publications