Abstract

The overall aim of this project is to elucidate the neural circuit mechanisms underlying the brain's ability to control its own sensory input. To address this issue, large number of single neurons (up to 128) will be recorded simultaneously through multi-electrode arrays implanted in multiple processing levels of the trigeminal somatosensory system of awake rates, during immobility and will performing exploratory wwhisking movements. Simultaneous recordings have recently been obtained in the trigeminal ganglion (Vg), principal (PrV) and spinal SpV) trigeminal nuclei, ventral posteromedial (VPM) thalamus, and somatosensory (SI) cortex.
Aim #1 is to continue current studies of spatiotemporally distributed """"""""shifting"""""""" receptive fields in neurons in the VPM and SI, which appear to be learned through motor experience.
Aim #2 is to determine whether active whisker movement produces and """"""""efference copy"""""""" which modulates sensory transmission according to the phase and """"""""motor intention"""""""" of the movement.
Aim #3 is to record from the same neurons in rats trained to discriminate among several tactile objects using active whisking.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS026722-13
Application #
6187209
Study Section
Special Emphasis Panel (ZRG2-BPO (01))
Program Officer
Heetderks, William J
Project Start
1988-12-01
Project End
2003-06-30
Budget Start
2000-07-01
Budget End
2003-06-30
Support Year
13
Fiscal Year
2000
Total Cost
$252,175
Indirect Cost

  Institution

Name
Suny Downstate Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
068552207
City
Brooklyn
State
NY
Country
United States
Zip Code
11203

  Publications

Chapin, John K (2004) Using multi-neuron population recordings for neural prosthetics. Nat Neurosci 7:452-5
Moxon, Karen A; Leiser, Steve C; Gerhardt, Greg A et al. (2004) Ceramic-based multisite electrode arrays for chronic single-neuron recording. IEEE Trans Biomed Eng 51:647-56
Chapin, J K (2000) Impact of neuroprosthetic applications on functional recovery. Prog Brain Res 128:115-20
Chapin, J K (2000) Neural prosthetic devices for quadriplegia. Curr Opin Neurol 13:671-5
Chapin, J K; Moxon, K A; Markowitz, R S et al. (1999) Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex. Nat Neurosci 2:664-70
Chapin, J K; Nicolelis, M A (1999) Principal component analysis of neuronal ensemble activity reveals multidimensional somatosensory representations. J Neurosci Methods 94:121-40
Nicolelis, M A; Lin, R C; Chapin, J K (1997) Neonatal whisker removal reduces the discrimination of tactile stimuli by thalamic ensembles in adult rats. J Neurophysiol 78:1691-706
Lin, R C; Nicolelis, M A; Chapin, J K (1997) Topographic and laminar organizations of the incertocortical pathway in rats. Neuroscience 81:641-51
Lin, R C; Nicolelis, M A; Zhou, H L et al. (1996) Calbindin-containing non-specific thalamocortical projecting neurons in the rat. Brain Res 711:50-5
Smith, S S; Chapin, J K (1996) The estrous cycle and the olivo-cerebellar circuit. I. Contrast enhancement of sensorimotor-correlated cerebellar discharge. Exp Brain Res 111:371-84

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