The overall aim of this project is to elucidate the neural circuit mechanisms underlying the brain's ability to control its own sensory input. To address this issue, large number of single neurons (up to 128) will be recorded simultaneously through multi-electrode arrays implanted in multiple processing levels of the trigeminal somatosensory system of awake rates, during immobility and will performing exploratory wwhisking movements. Simultaneous recordings have recently been obtained in the trigeminal ganglion (Vg), principal (PrV) and spinal SpV) trigeminal nuclei, ventral posteromedial (VPM) thalamus, and somatosensory (SI) cortex.
Aim #1 is to continue current studies of spatiotemporally distributed """"""""shifting"""""""" receptive fields in neurons in the VPM and SI, which appear to be learned through motor experience.
Aim #2 is to determine whether active whisker movement produces and """"""""efference copy"""""""" which modulates sensory transmission according to the phase and """"""""motor intention"""""""" of the movement.
Aim #3 is to record from the same neurons in rats trained to discriminate among several tactile objects using active whisking.
|Chapin, John K (2004) Using multi-neuron population recordings for neural prosthetics. Nat Neurosci 7:452-5|
|Moxon, Karen A; Leiser, Steve C; Gerhardt, Greg A et al. (2004) Ceramic-based multisite electrode arrays for chronic single-neuron recording. IEEE Trans Biomed Eng 51:647-56|
|Chapin, J K (2000) Impact of neuroprosthetic applications on functional recovery. Prog Brain Res 128:115-20|
|Chapin, J K (2000) Neural prosthetic devices for quadriplegia. Curr Opin Neurol 13:671-5|
|Chapin, J K; Moxon, K A; Markowitz, R S et al. (1999) Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex. Nat Neurosci 2:664-70|
|Chapin, J K; Nicolelis, M A (1999) Principal component analysis of neuronal ensemble activity reveals multidimensional somatosensory representations. J Neurosci Methods 94:121-40|
|Nicolelis, M A; Lin, R C; Chapin, J K (1997) Neonatal whisker removal reduces the discrimination of tactile stimuli by thalamic ensembles in adult rats. J Neurophysiol 78:1691-706|
|Lin, R C; Nicolelis, M A; Chapin, J K (1997) Topographic and laminar organizations of the incertocortical pathway in rats. Neuroscience 81:641-51|
|Lin, R C; Nicolelis, M A; Zhou, H L et al. (1996) Calbindin-containing non-specific thalamocortical projecting neurons in the rat. Brain Res 711:50-5|
|Smith, S S; Chapin, J K (1996) The estrous cycle and the olivo-cerebellar circuit. I. Contrast enhancement of sensorimotor-correlated cerebellar discharge. Exp Brain Res 111:371-84|
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