This is an application from a leading investigator in Borna disease virus (BDV) biology representing a competing renewal of a highly productive grant that represents the PI's major source of funding for basic research in BDV molecular biology and pathogenesis. The broad objective of the effort is to characterize BDV and to define viral and host factors that contribute to: (1) the low productivity of BDV infection, (2) its capacity to generate persistent infection, and (3) BDV neurotropism. The five specific aims include: (1) functional characterization of the BDV P protein, (2) analysis of BDV protein- protein interactions, (3) characterization of the BDV X protein, (4) isolation and characterization of cellular element (PRCE) binding proteins, and (5) establishment of a reverse genetic/recombinant BDV system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029425-10
Application #
6188083
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Kerza-Kwiatecki, a P
Project Start
1991-05-01
Project End
2003-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
10
Fiscal Year
2000
Total Cost
$554,346
Indirect Cost
Name
University of California Irvine
Department
Neurology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
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Williams, B L; Lipkin, W I (2006) Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. J Virol 80:8613-26
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Avellon, Ana; Casas, Inmaculada; Trallero, Gloria et al. (2003) Molecular analysis of echovirus 13 isolates and aseptic meningitis, Spain. Emerg Infect Dis 9:934-41
Briese, Thomas; Rambaut, Andrew; Pathmajeyan, Melissa et al. (2002) Phylogenetic analysis of a human isolate from the 2000 Israel West Nile virus epidemic. Emerg Infect Dis 8:528-31

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