The first long range goal of this project is to understand the neurophysiological mechanisms that contribute to lumbar spine function; the second is to understand the mechanisms by which spinal manipulation affects low back pain. Back pain is very common in our society, and the Department of Health and Human Services recently recommended spinal manipulation as one treatment. The proposed investigation is based on the premise that understanding the neural responses to vertebral joint movement will provide a rational basis for understanding sensory mechanisms contributing to low back pain and the mechanisms by which physical treatment helps relieve back pain. The experiments proposed use a systematic approach to determine the discharge characteristics of lumbar sensory neurons evoked by movement of the lumbar facets. Neurophysiological studies will be performed on single identified sensory neurons to test the following hypotheses: 1) that the discharges of group I, II, III and IV afferents in the lumbar spine are graded with the magnitude and direction of facet joint movement; 2) that the discharges of group III and IV afferents innervating muscles and deep tissues of the lumbar spine during facet joint movement are enhanced by muscle-fatigue induced metabolites, including potassium, lactic acid and diprotonated phosphate; and 3) that the discharges of these afferents is also enhanced by inflammatory mediators, including bradykinin, serotonin, PGE2 and PGI2.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS035300-01A1
Application #
2038347
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Program Officer
Cheung, Mary Ellen
Project Start
1997-09-01
Project End
2000-06-30
Budget Start
1997-09-01
Budget End
1998-06-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Kansas State University
Department
Anatomy/Cell Biology
Type
Schools of Veterinary Medicine
DUNS #
City
Manhattan
State
KS
Country
United States
Zip Code
66506
Pickar, J G; Bolton, P S (2012) Spinal manipulative therapy and somatosensory activation. J Electromyogr Kinesiol 22:785-94
Kang, Yu-Ming; Choi, Woo-Sung; Pickar, Joel G (2002) Electrophysiologic evidence for an intersegmental reflex pathway between lumbar paraspinal tissues. Spine (Phila Pa 1976) 27:E56-63
Kang, Y M; Wheeler, J D; Pickar, J G (2001) Stimulation of chemosensitive afferents from multifidus muscle does not sensitize multifidus muscle spindles to vertebral loads in the lumbar spine of the cat. Spine (Phila Pa 1976) 26:1528-36