Abstract

Nervous systems are characterized by an astounding degree of cellular diversity, yet our insights into the mechanisms of creating this diversity are limited. The molecular correlate to neuronal diversity are neuron-type specific gene expression programs. Sets of co-expressed genes that characterize an individual cell type are commonly referred to as gene batteries which are defined by their linkage to conserved, common c/s-regulatory elements. The nature of gene batteries for individual neuronal subtypes as well as their linked cis-regulatory elements are poorly described on a genome-wide level. We propose here to systematically decode cis-regulatory information on a genome-wide level and to determine the identity of a single neuron-specific gene expression program. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS039996-08
Application #
7451051
Study Section
Neurogenesis and Cell Fate Study Section (NCF)
Program Officer
Tagle, Danilo A
Project Start
2000-04-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
8
Fiscal Year
2008
Total Cost
$345,083
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Biochemistry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Doitsidou, Maria; Minevich, Gregory; Kroll, Jason R et al. (2018) A Caenorhabditis elegans Zinc Finger Transcription Factor, ztf-6, Required for the Specification of a Dopamine Neuron-Producing Lineage. G3 (Bethesda) 8:17-26
Bayer, Emily A; Hobert, Oliver (2018) Past experience shapes sexually dimorphic neuronal wiring through monoaminergic signalling. Nature 561:117-121
Weinberg, Peter; Berkseth, Matthew; Zarkower, David et al. (2018) Sexually Dimorphic unc-6/Netrin Expression Controls Sex-Specific Maintenance of Synaptic Connectivity. Curr Biol 28:623-629.e3
Gendrel, Marie; Atlas, Emily G; Hobert, Oliver (2016) A cellular and regulatory map of the GABAergic nervous system of C. elegans. Elife 5:
Gordon, Patricia M; Hobert, Oliver (2015) A competition mechanism for a homeotic neuron identity transformation in C. elegans. Dev Cell 34:206-19
Alqadah, Amel; Hsieh, Yi-Wen; Vidal, Berta et al. (2015) Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2. EMBO J 34:2574-89
Murgan, Sabrina; Kari, Willi; Rothbächer, Ute et al. (2015) Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors. Dev Cell 33:737-45
Kratsios, Paschalis; Pinan-Lucarré, Bérangère; Kerk, Sze Yen et al. (2015) Transcriptional coordination of synaptogenesis and neurotransmitter signaling. Curr Biol 25:1282-95
Howell, Kelly; White, John G; Hobert, Oliver (2015) Spatiotemporal control of a novel synaptic organizer molecule. Nature 523:83-7
Stefanakis, Nikolaos; Carrera, Ines; Hobert, Oliver (2015) Regulatory Logic of Pan-Neuronal Gene Expression in C. elegans. Neuron 87:733-50

Showing the most recent 10 out of 63 publications