description): The minibrain (Mnb) gene is located in the Down syndrome critical region of human chromosome 21. Evidence suggests that an elevated Mnb gene dosage, as in trisomy 21, contributes to Down syndrome phenotypes. The Mnb gene encodes a dual specificity tyrosine phosphorylation regulated kinase (DYRK) whose function in mammalian cells is currently unknown. The investigators plan to elucidate the cellular role of the Mnb kinase by identifying and characterizing substrates of this kinase as well as proteins that modulate its activity.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
1R03HD035870-01A1
Application #
2677047
Study Section
Pediatrics Subcommittee (CHHD)
Project Start
1998-03-01
Project End
2000-02-29
Budget Start
1998-03-01
Budget End
1999-02-28
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Institute for Basic Research in Dev Disabil
Department
Type
DUNS #
167205090
City
Staten Island
State
NY
Country
United States
Zip Code
10314
Chen-Hwang, Mo-Chou; Chen, Huey-Ru; Elzinga, Marshall et al. (2002) Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. J Biol Chem 277:17597-604