This application is for one year of support for the workshop 'The Mouse as a Instrumentfor Ear Research IV' to be held at The Jackson Laboratory (Jackson) in Bar HarborMaine on September 19-23, 2010. We are currently in the midst of a genetics revolutionthat promises to push 'breakthrough' biomedical research to new levels. A large part ofthis revolution depends upon the analysis of the relationships between genes and theireffects on complex biological systems and phenotypes. Investigators must becomeincreasingly skilled in the application of genetic models to address a variety of importantbiological questions. The objective of this workshop is to provide a forum for researchersand students to learn techniques relating to the use of mouse genetic tools tounderstand audio-sensory neurobiology in humans. Researchers using the mouse willbe able to expand their knowledge of techniques from other experts in the field workingwith other models and interest in issues relating to concordance between model systemsand translation to the clinic. This four day workshop will include both introductory andhigh level scientific talks in the morning and evening sessions, with afternoons set asidefor tutorials and hands-on sessions. Short presentations will elaborate on techniquesdemonstrated in the tutorials and provide examples of cutting edge research. Mostpresentations will be invited lectures by the organizers but there are times available forcontributed papers and short abstract talks. Ultimately, this workshop will bring studentsand established investigators with varying expertise and experience together to discusstheir research, identify areas of common interest and learn state of the art techniques inauditory research and data analysis.
This workshop is directly relevant to human health as its focus is on the use of the laboratory mouse to study and understand human auditory biology and disease. Promoting the responsible use of appropriate models is critical to the development of effective new therapeutic approaches to treating human disease.