Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DK063015-02
Application #
6698594
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
May, Michael K
Project Start
2003-01-21
Project End
2004-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$133,690
Indirect Cost
Name
University of Wisconsin Madison
Department
Surgery
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Lubner, Sam J; Kunnimalaiyaan, Muthusamy; Holen, Kyle D et al. (2011) A preclinical and clinical study of lithium in low-grade neuroendocrine tumors. Oncologist 16:452-7
Greenblatt, David Yu; Ndiaye, Mary; Chen, Herbert et al. (2010) Lithium inhibits carcinoid cell growth in vitro. Am J Transl Res 2:248-53
Adler, Joel T; Hottinger, Daniel G; Kunnimalaiyaan, Muthusamy et al. (2008) Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells. Surgery 144:956-61;discussion 961-2
Kunnimalaiyaan, Muthusamy; Vaccaro, Abram M; Ndiaye, Mary A et al. (2007) Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells. Mol Cancer Ther 6:1151-8
Kunnimalaiyaan, Muthusamy; Vaccaro, Abram M; Ndiaye, Mary A et al. (2006) Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J Biol Chem 281:39819-30
Kunnimalaiyaan, Muthusamy; Chen, Herbert (2006) The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? Anticancer Drugs 17:139-42
Van Gompel, Jamie J; Kunnimalaiyaan, Muthusamy; Holen, Kyle et al. (2005) ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Mol Cancer Ther 4:910-7
Kunnimalaiyaan, Muthusamy; Traeger, Kelly; Chen, Herbert (2005) Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol 289:G636-42
Kunnimalaiyaan, Muthusamy; Yan, Sonia; Wong, Francis et al. (2005) Hairy Enhancer of Split-1 (HES-1), a Notch1 effector, inhibits the growth of carcinoid tumor cells. Surgery 138:1137-42; discussion 1142
Musunuru, Sandeepa; Carpenter, Jennifer E; Sippel, Rebecca S et al. (2005) A mouse model of carcinoid syndrome and heart disease. J Surg Res 126:102-5

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