Methylmercury (MeHg) is a ubiquitous environmental pollutant. The neurotoxicity of MeHg and the high susceptibility of the developing brain are well established both in humans and experimental animals. Prenatally exposed children display a range of effects varying from severe cerebral palsy to subtle developmental delays. Many of the more subtle effects of developmental MeHg exposure can be permanent, including behavioral abnormalities and loss of IQ, and impart a significant cost to society as a whole. It is estimated that as many as 15% of American women of childbearing age have total blood mercury concentrations at a level above that associated with loss of IQ (>3.5

Public Health Relevance

Methylmercury (MeHg) is a ubiquitous environmental pollutant. The neurotoxicity of high levels of MeHg and the increased susceptibility of the developing brain are well established both in humans and experimental animals. Prenatally exposed children display a range of effects varying from severe cerebral palsy to subtle developmental delays (Castoldi et al., 2001). Many of the more subtle effects of developmental MeHg exposure can be permanent, including behavioral abnormalities and loss of IQ. It is estimated that as many as 15% of American women of childbearing age have total blood mercury concentrations at a level above that associated with loss of IQ (>3.5

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21ES019104-02
Application #
7944036
Study Section
Special Emphasis Panel (ZDA1-GXM-A (03))
Program Officer
Mcallister, Kimberly A
Project Start
2009-09-30
Project End
2013-03-31
Budget Start
2010-07-01
Budget End
2013-03-31
Support Year
2
Fiscal Year
2010
Total Cost
$416,457
Indirect Cost
Name
University of Wisconsin Milwaukee
Department
Miscellaneous
Type
Other Domestic Higher Education
DUNS #
627906399
City
Milwaukee
State
WI
Country
United States
Zip Code
53201
Mora-Zamorano, Francisco X; Svoboda, Kurt R; Carvan 3rd, Michael J (2016) The Nicotine-Evoked Locomotor Response: A Behavioral Paradigm for Toxicity Screening in Zebrafish (Danio rerio) Embryos and Eleutheroembryos Exposed to Methylmercury. PLoS One 11:e0154570
Liu, Qing; Basu, Niladri; Goetz, Giles et al. (2013) Differential gene expression associated with dietary methylmercury (MeHg) exposure in rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio). Ecotoxicology 22:740-51
Basu, Niladri; Head, Jessica; Nam, Dong-Ha et al. (2013) Effects of methylmercury on epigenetic markers in three model species: mink, chicken and yellow perch. Comp Biochem Physiol C Toxicol Pharmacol 157:322-7
Xu, Xiaojuan; Weber, Daniel; Carvan 3rd, Michael J et al. (2012) Comparison of neurobehavioral effects of methylmercury exposure in older and younger adult zebrafish (Danio rerio). Neurotoxicology 33:1212-8
Kwon, Sae Yun; Blum, Joel D; Carvan, Michael J et al. (2012) Absence of fractionation of mercury isotopes during trophic transfer of methylmercury to freshwater fish in captivity. Environ Sci Technol 46:7527-34