Intracranial pressure (ICP) monitoring is an essential diagnostic tool for the efficient treatment of patients with brain injuries (e.g. traumatic brain injuries (TBIs)) and cerebrospinal fluid outflow disorders (e.g. hydrocephalus). Clinical trials have shown that ICP monitoring decreases the mortality rate and minimizes secondary injuries. Various ICP monitoring systems have been successful so far in accurately monitoring ICP, but: (a) they have high probability of infection (up to 15%), (b) they do not allow long-term ICP monitoring and (c) they are not MRI (Magnetic Resonance Imaging) compatible. Taking advantage of recent developments in the MicroElectroMechanical Systems (MEMS) field, we propose an 'Intracranial Pressure Micro Stick'(IP

Public Health Relevance

Intracranial pressure (ICP) monitoring is an important diagnostic tool for accessing the pathological condition of patients with traumatic brain injury (TBI), congenital or acquired hydrocephalus or mass lesions. This work aims to develop a new class of implantable ICP monitoring devices that will provide better management and efficient treatment of patients with elevated ICP.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21NS062313-01A2
Application #
7779574
Study Section
Neurotechnology Study Section (NT)
Program Officer
Hicks, Ramona R
Project Start
2009-09-01
Project End
2011-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$172,672
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Mishra, Bibhudatta; Ghannad-Rezaie, Mostafa; Li, Jiaxing et al. (2014) Using microfluidics chips for live imaging and study of injury responses in Drosophila larvae. J Vis Exp :e50998
Ghannad-Rezaie, Mostafa; Wang, Xing; Mishra, Bibhudatta et al. (2012) Microfluidic chips for in vivo imaging of cellular responses to neural injury in Drosophila larvae. PLoS One 7:e29869