? ? The objective of this competitive renewal application is to provide """"""""non-standard positron emitting radionuclides"""""""" for collaborative research and as a service to investigators funded to carry out cancer research. To achieve this goal two research projects are proposed: ? ? 1. In research Project 1 we will continue to develop high yield techniques for the production of the radionuclides 60Cu, 61Cu, 64Cu, 66Ga, 86Y, 94mTc, 76Br, 77Br and 124I. ? ? 2. The radionuclides developed in research Project 1 have high-energy positrons and in several cases gamma rays that are emitted in coincidence with the positron. The imaging physics of these nuclides will be evaluated and techniques to improve image resolution of these high-energy positron emitters and improve quantification developed. ? ? These two research projects will support collaborative projects with investigators interested in oncologic imaging. Several of the collaborative research projects will utilize the microPET imaging facility in the Division of Radiological Sciences at Washington University. ? ? The grant will also supply the long-lived radionuclides to NCI-funded investigators who cannot obtain these nuclides from other sources. A training program is proposed and dissemination of information is an important part of this resource. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects (R24)
Project #
5R24CA086307-08
Application #
7107211
Study Section
Special Emphasis Panel (ZCA1-SRRB-C (M3))
Program Officer
Croft, Barbara
Project Start
1999-09-01
Project End
2009-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
8
Fiscal Year
2006
Total Cost
$936,532
Indirect Cost
Name
Washington University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Xie, Fang; Cai, Huawei; Peng, Fangyu (2017) 64CuCl2 PET/CT imaging of mouse muscular injury induced by electroporation. Am J Nucl Med Mol Imaging 7:33-39
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O'Neill, Allison F; Dearling, Jason L J; Wang, Yuchuan et al. (2014) Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody. Clin Cancer Res 20:678-87
Yuan, Jianchao; Zhang, Haiyuan; Kaur, Harpreet et al. (2013) Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymer targeting tumor angiogenesis: tumor localization visualized by positron emission tomography. Mol Imaging 12:203-12
Pressly, Eric D; Pierce, Richard A; Connal, Luke A et al. (2013) Nanoparticle PET/CT imaging of natriuretic peptide clearance receptor in prostate cancer. Bioconjug Chem 24:196-204
Liu, Yongjian; Pierce, Richard; Luehmann, Hannah P et al. (2013) PET imaging of chemokine receptors in vascular injury-accelerated atherosclerosis. J Nucl Med 54:1135-41

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