Abstract

)This is an application to establish resources to facilitate cancer research at the Fels Institute for Cancer Research and Molecular Biology at Temple University School of Medicine. The resources will serve a group of ten National Cancer Institute-funded investigators and several other National Institutes of Health-funded investigators. All of these investigators are working on cancer-related research. The core facilities to be funded by this proposal include a Microscopy and Imaging Facility, a Flow Cytometry Facility, a Gene Targeting and Transfer Facility, and a Computer Resources Facility. Together these cores will facilitate the research by the major and minor users at the Fels Institute.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects (R24)
Project #
5R24CA088261-04
Application #
6732076
Study Section
Special Emphasis Panel (ZCA1-SRRB-E (M3))
Program Officer
Mietz, Judy
Project Start
2001-04-01
Project End
2006-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
4
Fiscal Year
2004
Total Cost
$254,657
Indirect Cost

  Institution

Name
Temple University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122

  Publications

Sotillo, Elena; Garriga, Judit; Kurimchak, Alison et al. (2008) Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts. J Biol Chem 283:11280-92
Salerno, Dominic; Hasham, Muneer G; Marshall, Renee et al. (2007) Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes. Gene 405:65-78
Nagl Jr, Norman G; Wang, Xiaomei; Patsialou, Antonia et al. (2007) Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control. EMBO J 26:752-63
Nagl Jr, Norman G; Zweitzig, Daniel R; Thimmapaya, Bayar et al. (2006) The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest. Cancer Res 66:1289-93
Marshall, Renee M; Grana, Xavier (2006) Mechanisms controlling CDK9 activity. Front Biosci 11:2598-613
Miyara, Faical; Han, Zhiming; Gao, Shaorong et al. (2006) Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones. Dev Biol 289:206-17
Mangan, J K; Tantravahi, R V; Rane, S G et al. (2006) Granulocyte colony-stimulating factor-induced upregulation of Jak3 transcription during granulocytic differentiation is mediated by the cooperative action of Sp1 and Stat3. Oncogene 25:2489-99
Nagl Jr, Norman G; Patsialou, Antonia; Haines, Dale S et al. (2005) The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest. Cancer Res 65:9236-44
Patsialou, Antonia; Wilsker, Deborah; Moran, Elizabeth (2005) DNA-binding properties of ARID family proteins. Nucleic Acids Res 33:66-80
Wang, Xiaomei; Liao, Da-Wei; Scoy, Michael Van et al. (2005) Monoclonal antibodies reactive with the BAF155 (SMARCC1) and BAF170 (SMARCC2) components of human SWI/SNF-related complexes. Hybridoma (Larchmt) 24:55-7

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