The goals of the proposed Minority Research Infrastructure Support Program (MRISP) at the Old Westbury Neuroscience Research Institute (OWNRI) are: 1) To conduct studies in the areas of neuroscience that are of importance that are of importance to the understanding of its molecular processes; 2) To increase minority representation in the fields of neuroscience, neuroimmunology and mental health by providing a state-of-the-art research experience and associated activities, e.g., seminars, lectures, etc., to new faculty and students that will be developed as part of the program activities. 3) To disseminate findings through scholarly publications and presentations; and 4) To build a strong infrastructure in neuroscience so that the capacity of Old Westbury in regard to mental health/neuroscience activities is increased. The College at Old Westbury is ideally suited to carry out this mission its faculty is developing expertise in neuroscience is demonstrated by their peer-reviewed publications, particularly in the fields of morphine neurobiology and neuroscience. The program has a multi-ethnic faculty and a high percentage of minority students that choose science as a major. The major research projects incorporated into this proposal are designed to address two NIMH priorities: A) Effects of endogenous morphine on neural processes, not related to substance phenomena; and B) Interaction of parasitic opioid peptides in modulation host behavior, providing information on their ability to alter/modify host behavior.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Resource-Related Research Projects (R24)
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Special Emphasis Panel (ZMH1-CRB-B (02))
Program Officer
Mays, Robert A
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College at Old Westbury
Schools of Arts and Sciences
Old Westbury
United States
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Nieto-Fernandez, F; Andrieux, S; Idrees, S et al. (2009) The effect of opioids and their antagonists on the nocifensive response of Caenorhabditis elegans to noxious thermal stimuli. Invert Neurosci 9:195-200
Stefano, George B; Kream, Richard M; Mantione, Kirk J et al. (2008) Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: implications for cancer biology. Semin Cancer Biol 18:199-210
Stefano, George B; Kream, Richard M (2007) Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review). Int J Mol Med 20:837-41
Pryor, Stephen C; Nieto, Fernando; Henry, Sherwyn et al. (2007) The effect of opiates and opiate antagonists on heat latency response in the parasitic nematode Ascaris suum. Life Sci 80:1650-5
Cheng, Jeanette; Zhang, Chen; Han, Ji-Sheng et al. (2007) TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues. Med Sci Monit 13:BR163-7
Stefano, George B; Bianchi, Enrica; Guarna, Massimo et al. (2007) Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis. Med Sci Monit 13:RA91-102
Mantione, Kirk J; Kim, Celline; Stefano, George B (2006) Morphine regulates gill ciliary activity via coupling to nitric oxide release in a bivalve mollusk: opiate receptor expression in gill tissues. Med Sci Monit 12:BR195-200
Esch, Tobias; Kim, Jae Won; Stefano, George B (2006) Neurobiological implications of eating healthy. Neuro Endocrinol Lett 27:21-33
Kream, Richard M; Stefano, George B (2006) De novo biosynthesis of morphine in animal cells: an evidence-based model. Med Sci Monit 12:RA207-19
Stefano, George B; Fricchione, Gregory L; Esch, Tobias (2006) Relaxation: molecular and physiological significance. Med Sci Monit 12:HY21-31

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