This application proposes to establish a unique training program in cancer imaging research. The program is designed to train both medical post-doctoral candidates with extensive experience In medical imaging, oncology or cancer biology, and basic-science post-doctoral candidates with extensive experience in imaging technology or cancer biology who desire to become independent investigators. Trainees will utilize the wide variety of imaging resources available through the Departments of Radiology at Vanderbilt University Medical Center and Meharry Medical College, The Vanderbilt In-Vive Imaging Center and The Vanderbilt/Keck Free Electron Laser Facility. Individual trainee research projects will be Integrated with ongoing projects in the cancer laboratories of the Vanderbilt/Meharry Alliance with special emphasis on the projects of The Vanderbilt-lngram Cancer Center and the Consortium for Mouse Models of Human Cancer. Each trainee will be assigned two or more mentors representing both the imaging sciences and cancer biology disciplines. The specialized curriculum provided by this training program will establish two new courses, a new cancer imaging seminar and a new cancer imaging Journal club. The curriculum is also supplemented through existing courses offered by the cooperating departments: Biomedical Engineering, Electrical Engineering/Computer Sciences, Cell/Cancer Biology, Mathematics, Physics, Biochemistry and Clinical Investigation. The program leadership will consist of three co-directors reflecting the multidisciplinary nature of the training program. Ronald R. Price, Ph.D. will coordinate the specialized curriculum components specific to training in the imaging sciences. Lynn Matrisian, Ph.D. will coordinate the curriculum components specific to training in the biological sciences. Charles DePriest, M.D. will direct minority recruitment and will coordinate training components specific to post-doctoral physician scientists with prior experience in medical imaging. The training program is designed to provide a two or three year (dependent upon trainee background) intensive research experience using imaging methods and technology which when successfully completed, will prepare individuals to become active participants in a multidisciplinary team of cancer researchers.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Education Projects (R25)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Myrick, Dorkina C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Schools of Medicine
United States
Zip Code
Zhang, Qin; Jeppesen, Dennis K; Higginbotham, James N et al. (2018) Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cell Mol Gastroenterol Hepatol 5:627-629.e6
Herring, Charles A; Banerjee, Amrita; McKinley, Eliot T et al. (2018) Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut. Cell Syst 6:37-51.e9
Hormuth 2nd, David A; Weis, Jared A; Barnes, Stephanie L et al. (2018) Biophysical Modeling of In Vivo Glioma Response After Whole-Brain Radiation Therapy in a Murine Model of Brain Cancer. Int J Radiat Oncol Biol Phys 100:1270-1279
Kusunose, Jiro; Caskey, Charles F (2018) Fast, Low-Frequency Plane-Wave Imaging for Ultrasound Contrast Imaging. Ultrasound Med Biol 44:2131-2142
Banerjee, Amrita; McKinley, Eliot T; von Moltke, Jakob et al. (2018) Interpreting heterogeneity in intestinal tuft cell structure and function. J Clin Invest 128:1711-1719
Herring, Charles A; Chen, Bob; McKinley, Eliot T et al. (2018) Single-Cell Computational Strategies for Lineage Reconstruction in Tissue Systems. Cell Mol Gastroenterol Hepatol 5:539-548
Simmons, Alan J; Scurrah, Cherié R; McKinley, Eliot T et al. (2016) Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. Sci Signal 9:rs11
Sorace, Anna G; Quarles, C Chad; Whisenant, Jennifer G et al. (2016) Trastuzumab improves tumor perfusion and vascular delivery of cytotoxic therapy in a murine model of HER2+ breast cancer: preliminary results. Breast Cancer Res Treat 155:273-84
Skinner, J T; Moots, P L; Ayers, G D et al. (2016) On the Use of DSC-MRI for Measuring Vascular Permeability. AJNR Am J Neuroradiol 37:80-7
Abramson, Richard G; Arlinghaus, Lori R; Dula, Adrienne N et al. (2016) MR Imaging Biomarkers in Oncology Clinical Trials. Magn Reson Imaging Clin N Am 24:11-29

Showing the most recent 10 out of 65 publications