The overall goal of the undergraduate and graduate components of our IMSD program is to increase the number of underrepresented students earning PhDs in biomedical sciences. At the undergraduate level, we continue to focus on activities designed to enable students to excel in foundation courses (chemistry, calculus, and biology), to graduate in biology with GPAs > 3.0, and to enter biomedical science-related PhD programs. For freshmen and sophomores in the Biology Undergraduate Scholars Program (BUSP), we have developed a structured program of supplemental course work in chemistry, math, and biology; a lab skills course to prepare them for their research experiences, personal and academic advising, and a two quarter requirement for engagement in faculty-mentored research. For juniors and seniors participating in the BUSP-Honors Research program, we provide opportunities for significant engagement in research projects that take full advantage of the facilities and expertise on the campus. These activities have resulted in increased numbers of BUSP students earning a baccalaureate degree in biology with a GPA > 3.0 [currently, averaging 42% of BUSP participants (2002-06)] and increased numbers of students pursuing a PhD (currently 60% of BUSP-Honors students have pursued postgraduate education and 27% of BUSP-Honors students have pursued biomedical PhDs). Our aspirational goal for the IMSD-supported BUSP/BUSP-Honors students is to increase to at least 60% the number of them who pursue a PhD in the biomedical sciences. To help achieve this goal, we will continue to expand the pool from which we select the IMSD-funded BUSP students and to provide new program activities designed to engender in students an enhanced interest in and understanding of research careers and how to get there. The latter will include increased interaction with faculty from other research universities (via their visits to UC Davis) and increased interaction with UC Davis IMSD graduate students who are pursuing or have completed PhD programs. For the graduate program, our specific aims are to maintain the high success of the IMSD Fellows in advancing to candidacy; increase the percentage of students who complete their PhD program (through more focused mentoring); increase involvement of the IMSD Fellows with the campus T32 activities, focusing initially on the Molecular & Cellular T32; increase interaction of the Fellows with the BUSP/BUSP-Honors students; and continue the increase in acceptance rate of underrepresented students into the 12 participating graduate programs to that at least equivalent to the acceptance rate for non-underrepresented students.

Public Health Relevance

The goal of our proposal is to increase the diversity of students pursuing a PhD in biomedical sciences and entering a research career in the biomedical sciences. To achieve this goal, we have developed a coordinated series of enrichment and advising activities for underrepresented undergraduates in the biological sciences and a series of professional development activities to enhance the skills of underrepresented first year PhD students in graduate programs that prepare students for biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Education Projects (R25)
Project #
5R25GM056765-20
Application #
9292334
Study Section
Training and Workforce Development Subcommittee - D (TWD-D)
Program Officer
Ravichandran, Veerasamy
Project Start
1998-02-01
Project End
2019-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
20
Fiscal Year
2017
Total Cost
$400,857
Indirect Cost
$23,072
Name
University of California Davis
Department
Physiology
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Rincón, Esther; Rocha-Gregg, Briana L; Collins, Sean R (2018) A map of gene expression in neutrophil-like cell lines. BMC Genomics 19:573
Jiang, Guochun; Nguyen, Don; Archin, Nancie M et al. (2018) HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest 128:1190-1198
Finno, Carrie J; Bordbari, Matthew H; Gianino, Giuliana et al. (2018) An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice. Free Radic Biol Med 120:289-302
Chung, Nhi; Bogliotti, Yanina S; Ding, Wei et al. (2017) Active H3K27me3 demethylation by KDM6B is required for normal development of bovine preimplantation embryos. Epigenetics 12:1048-1056
Byndloss, Mariana X; Olsan, Erin E; Rivera-Chávez, Fabian et al. (2017) Microbiota-activated PPAR-? signaling inhibits dysbiotic Enterobacteriaceae expansion. Science 357:570-575
Sun, Xiaolin; Wei, Haiying; Young, Dominique E et al. (2017) Differential pulmonary effects of wintertime California and China particulate matter in healthy young mice. Toxicol Lett 278:1-8
Webster, Kaitlyn A; Schach, Ursula; Ordaz, Angel et al. (2017) Dmrt1 is necessary for male sexual development in zebrafish. Dev Biol 422:33-46
Jena, Prasant K; Sheng, Lili; Liu, Hui-Xin et al. (2017) Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment. Am J Pathol 187:1800-1813
Madrigal, Justin L; Stilhano, Roberta; Silva, Eduardo A (2017) Biomaterial-Guided Gene Delivery for Musculoskeletal Tissue Repair. Tissue Eng Part B Rev 23:347-361
Olsan, Erin E; Byndloss, Mariana X; Faber, Franziska et al. (2017) Colonization resistance: The deconvolution of a complex trait. J Biol Chem 292:8577-8581

Showing the most recent 10 out of 62 publications