The long-term goal of this proposal is to prepare trainees from underrepresented minority groups for careers as outstanding research scientists and leaders in the biomedical community. This training program will provide research and education opportunities in microbiology and immunology, that are of direct relevance to many of the health problems that disproportionately affect minorities and medically underserved groups (e.g., arthritis, cancer, cardiovascular disease, diabetes, HIV and other STDs, and respiratory diseases). The program will create a highly cohesive cadre of trainees with shared scientific interests and experiences, and will leverage the outstanding training environment created by the University of Rochester (UR)'s Clinical and Translational Sciences Institute and multiple predoctoral T32 awards in microbiology and immunology. Trainees will also benefit from a planned expansion of research opportunities in the area of immunology and infectious diseases, and from strong institutional support for this established and successful PREP program. This program has three specific objectives. First, a supportive, productive, and exciting environment will be created, in which trainees will conduct outstanding research in microbiology, immunology, and virology while working as full-time laboratory technicians under the supervision of a program faculty member. This will be achieved by bringing together a highly interactive and experienced group of well-funded faculty concerned with the advancement of underrepresented minority trainees, whose research interests span a diverse range of topics, and whose laboratories use a wide array of experimental approaches.
The second aim of the program is to provide high quality educational opportunities that will prepare trainees for future doctoral studies. To this end, each trainee will perform an independent research project under the supervision of a faculty mentor. In addition, an individual plan of study will be developed for each trainee, tailored specifically to meet the unique needs of that individual. This will include a small number of carefully selected courses, designed to (a) provide instruction in needed skills/area, (b) demonstrate academic preparedness for doctoral studies, and (c) gain academic credit towards the Ph.D. at the University of Rochester.
The third aim of the program is to provide a highly enriched learning environment, with strong peer support. Enrichment activities will include instruction in scientific survival and communication skills, attendance at national scientific meetings, participation in an annual symposium and a GRE preparation course, and the opportunity to select, invite and meet with extramural seminar speakers. Finally a trainee social network will be created, and trainees will be matched with peer mentors for collegiality, collaborations and support. Public Health Relevance Statement Individuals from underpresented minorities will gain the education and training that will allow them to acquire the essential academic credentials and research skills needed to allow them to enter and complete Ph.D. programs at select institutions. With these degrees they will be able to become productive research scientists in areas that address reducing health disparities.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Education Projects (R25)
Project #
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Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Bender, Michael T
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University of Rochester
Schools of Dentistry
United States
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Xie, Jinglin L; Qin, Longguang; Miao, Zhengqiang et al. (2017) The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation. Nat Commun 8:499
Jacques, Robert; Edholm, Eva-Stina; Jazz, Sanchez et al. (2017) Xenopus-FV3 host-pathogen interactions and immune evasion. Virology 511:309-319
Saputo, Sarah; Norman, Kaitlyn L; Murante, Thomas et al. (2016) Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans. Genetics 203:1217-33
Skrombolas, Denise; Wylie, Isabel; Maharaj, Shivana et al. (2015) Characterization of an IL-12 p40/p35 Truncated Fusion Protein That can Inhibit the Action of IL-12. J Interferon Cytokine Res 35:690-7
Singh, Vir B; Wooten, Alicia K; Jackson, Joseph W et al. (2015) Investigating the role of ankyrin-rich membrane spanning protein in human immunodeficiency virus type-1 Tat-induced microglia activation. J Neurovirol 21:186-98
Chaand, Mudit; Miller, Kelly A; Sofia, Madeline K et al. (2015) Type 3 Secretion System Island Encoded Proteins Required for Colonization by Non-O1/non-O139 Serogroup V. cholerae. Infect Immun :
Polesskaya, Oksana; Wong, Christopher; Lebron, Luis et al. (2014) MLK3 regulates fMLP-stimulated neutrophil motility. Mol Immunol 58:214-22
Edholm, Eva-Stina; Albertorio Saez, Liz-Marie; Gill, Ann L et al. (2013) Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians. Proc Natl Acad Sci U S A 110:14342-7
Abranches, Jacqueline; Tijerina, Pamella; Aviles-Reyes, Alejandro et al. (2013) The cell wall-targeting antibiotic stimulon of Enterococcus faecalis. PLoS One 8:e64875
Snell, Sara B; Foster, Thomas H; Haidaris, Constantine G (2012) Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy. Photochem Photobiol 88:596-603

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