Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29GM055042-01
Application #
2023632
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1997-01-01
Project End
2001-12-31
Budget Start
1997-01-01
Budget End
1997-12-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Rochester
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Dutta, Sanjib; Batori, Vincent; Koide, Akiko et al. (2005) High-affinity fragment complementation of a fibronectin type III domain and its application to stability enhancement. Protein Sci 14:2838-48
Zhao, Changqing; Koide, Akiko; Abrams, Judith et al. (2003) Mutation of Leu-536 in human estrogen receptor-alpha alters the coupling between ligand binding, transcription activation, and receptor conformation. J Biol Chem 278:27278-86
Richards, Julie; Miller, Michelle; Abend, Johanna et al. (2003) Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin. J Mol Biol 326:1475-88
Batori, Vincent; Koide, Akiko; Koide, Shohei (2002) Exploring the potential of the monobody scaffold: effects of loop elongation on the stability of a fibronectin type III domain. Protein Eng 15:1015-20
Koide, Akiko; Abbatiello, Stacy; Rothgery, Lisa et al. (2002) Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor. Proc Natl Acad Sci U S A 99:1253-8
Koide, A; Jordan, M R; Horner, S R et al. (2001) Stabilization of a fibronectin type III domain by the removal of unfavorable electrostatic interactions on the protein surface. Biochemistry 40:10326-33
Huang, X; Yang, X; Luft, B J et al. (1998) NMR identification of epitopes of Lyme disease antigen OspA to monoclonal antibodies. J Mol Biol 281:61-7
Koide, A; Bailey, C W; Huang, X et al. (1998) The fibronectin type III domain as a scaffold for novel binding proteins. J Mol Biol 284:1141-51