The Colorado Craniosynostosis Registry was established on April 15, 1986 to investigate the occureence of craniosynostosis (CS) in Colorado. Statewide concern arose after a 1978 cluster report and again after a 1983 study that found a higher birth prevalence of CS in Colorado than in Atlanta. During the first six months of operation, 218 eligible children were reported to the registry, corresponding to an estimated birth prevalence of almost one percent statewide, with county-specific birth prevalences as high as 18 percent. This population-based case-control study will seek to identify risk factors for CS occurrence in Colorado. Children with CS will be identified prospectively through the statewide registry. Control children will be identified through random sampling of Colorado birth certificates. Mothers of normal and affected children will be interviewed by telephone regarding their child's exposure to potential risk factors for CS such as obstetric, occupational, and environmental factors. Hospital records of the mother and child will be reviewed for record of exposure to potential risk factors such as abnormal lie and birth trauma. The exposure histories of control children and children with CS will be compared using stratified analysis and logistic regression. Some analyses will estimate the association between CS and previously hypothesized risk factors, like fetal head constraint, while others will seek evidence of association with newly hypothesized risk factors for CS such as high attitude. Familial aggregation of CS will be examined in the same manner, with furhter genetic epidemiologic analysis as indicated. The analyses will be repeated among controls and children with CS of unknown etiology. The occurrence of CS is largely unexplained. Increased understanding of factors associated with this common defect may provide clues for future epidemiologic and laboratory research, and may provide a first step toward primary prevention of the defect.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29HD022831-01A1
Application #
3469432
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1988-02-01
Project End
1993-01-31
Budget Start
1988-02-01
Budget End
1989-01-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
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Alderman, B W; Zamudio, S; Baron, A E et al. (1995) Increased risk of craniosynostosis with higher antenatal maternal altitude. Int J Epidemiol 24:420-6
Bradley, C M; Alderman, B W; Williams, M A et al. (1995) Parental occupations as risk factors for craniosynostosis in offspring. Epidemiology 6:306-10
Alderman, B W; Bradley, C M; Greene, C et al. (1994) Increased risk of craniosynostosis with maternal cigarette smoking during pregnancy. Teratology 50:13-8