Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Unknown (R35)
Project #
5R35AG007911-02
Application #
3814138
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
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Selkoe, D J; Yamazaki, T; Citron, M et al. (1996) The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Ann N Y Acad Sci 777:57-64
Koo, E H; Squazzo, S L; Selkoe, D J et al. (1996) Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J Cell Sci 109 ( Pt 5):991-8
Querfurth, H W; Wijsman, E M; St George-Hyslop, P H et al. (1995) Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Brain Res Mol Brain Res 28:319-37
Citron, M; Teplow, D B; Selkoe, D J (1995) Generation of amyloid beta protein from its precursor is sequence specific. Neuron 14:661-70
Haass, C; Koo, E H; Capell, A et al. (1995) Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. J Cell Biol 128:537-47
Yamazaki, T; Selkoe, D J; Koo, E H (1995) Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J Cell Biol 129:431-42
Qiu, W Q; Ferreira, A; Miller, C et al. (1995) Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci 15:2157-67
Podlisny, M B; Ostaszewski, B L; Squazzo, S L et al. (1995) Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem 270:9564-70
Lemere, C A; Munger, J S; Shi, G P et al. (1995) The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am J Pathol 146:848-60

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