Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG008303-08
Application #
2050149
Study Section
Special Emphasis Panel (NSS)
Program Officer
Finkelstein, David B
Project Start
1989-05-02
Project End
1998-04-30
Budget Start
1996-06-01
Budget End
1998-04-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Pathology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Gray, M D; Shen, J C; Kamath-Loeb, A S et al. (1997) The Werner syndrome protein is a DNA helicase. Nat Genet 17:100-3
Ye, L; Miki, T; Nakura, J et al. (1997) Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Med Genet 68:494-8
Ogburn, C E; Oshima, J; Poot, M et al. (1997) An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum Genet 101:121-5
Yu, C E; Oshima, J; Wijsman, E M et al. (1997) Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am J Hum Genet 60:330-41
Yu, C E; Oshima, J; Hisama, F M et al. (1996) A YAC, P1, and cosmid contig and 17 new polymorphic markers for the Werner syndrome region at 8p12-p21. Genomics 35:431-40
Goddard, K A; Yu, C E; Oshima, J et al. (1996) Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers. Am J Hum Genet 58:1286-302
Oshima, J; Yu, C E; Piussan, C et al. (1996) Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum Mol Genet 5:1909-13
Oshima, J; Campisi, J; Tannock, T C et al. (1995) Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol 162:277-83
Yu, C E; Anderson, L; Oshima, J et al. (1994) Dinucleotide repeat polymorphism at the D8S131 locus. Hum Mol Genet 3:211
Olson, J M; Wijsman, E M (1994) Design and sample-size considerations in the detection of linkage disequilibrium with a disease locus. Am J Hum Genet 55:574-80

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