Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI027690-18
Application #
7022244
Study Section
Special Emphasis Panel (NSS)
Program Officer
Black, Paul L
Project Start
2004-02-15
Project End
2009-01-31
Budget Start
2006-02-01
Budget End
2007-01-31
Support Year
18
Fiscal Year
2006
Total Cost
$830,707
Indirect Cost
Name
Rutgers University
Department
Type
Schools of Medicine
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Boyer, Paul L; Smith, Steven J; Zhao, Xue Zhi et al. (2018) Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase. J Virol 92:
Das, Kalyan; Martinez, Sergio E; Arnold, Eddy (2017) Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob Agents Chemother 61:
Balzarini, Jan; Menni, Michael; Das, Kalyan et al. (2017) Guanine ?-carboxy nucleoside phosphonate (G-?-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses. Biochem Pharmacol 136:51-61
Miller, Matthew T; Tuske, Steve; Das, Kalyan et al. (2016) Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer. Protein Sci 25:46-55
Mullins, Nicholas D; Maguire, Nuala M; Ford, Alan et al. (2016) Exploring the role of the ?-carboxyphosphonate moiety in the HIV-RT activity of ?-carboxy nucleoside phosphonates. Org Biomol Chem 14:2454-65
Das, Kalyan; Balzarini, Jan; Miller, Matthew T et al. (2016) Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. ACS Chem Biol 11:2158-64
Neogi, Ujjwal; Häggblom, Amanda; Singh, Kamalendra et al. (2016) Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries. J Antimicrob Chemother 71:367-71
Bauman, Joseph D; Harrison, Jerry Joe E K; Arnold, Eddy (2016) Rapid experimental SAD phasing and hot-spot identification with halogenated fragments. IUCrJ 3:51-60
Lee, Won-Gil; Frey, Kathleen M; Gallardo-Macias, Ricardo et al. (2015) Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 25:4824-7
Boyer, Paul L; Das, Kalyan; Arnold, Eddy et al. (2015) Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase. Antimicrob Agents Chemother 59:7184-96

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