Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37DA002749-14S1
Application #
3482646
Study Section
Special Emphasis Panel (SRCD (02))
Project Start
1981-01-01
Project End
1993-04-30
Budget Start
1989-05-01
Budget End
1990-04-30
Support Year
14
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Arts and Sciences
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Ramsey, Amy J; Laakso, Aki; Cyr, Michel et al. (2008) Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine. Neuropsychopharmacology 33:2701-14
Allen, Richard M; Dykstra, Linda A; Carelli, Regina M (2007) Continuous exposure to the competitive N-methyl-D: -aspartate receptor antagonist, LY235959, facilitates escalation of cocaine consumption in Sprague-Dawley rats. Psychopharmacology (Berl) 191:341-51
Carrigan, Kelly A; Dykstra, Linda A (2007) Behavioral effects of morphine and cocaine in M1 muscarinic acetylcholine receptor-deficient mice. Psychopharmacology (Berl) 191:985-93
Hughes, Christine E; Sigmon, Stacey C; Pitts, Raymond C et al. (2005) Morphine tolerance as a function of ratio schedule: response requirement or unit price? J Exp Anal Behav 83:281-96
Medvedev, Ivan O; Gainetdinov, Raul R; Sotnikova, Tatyana D et al. (2005) Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice. Psychopharmacology (Berl) 180:408-13
Allen, Richard M; Carelli, Regina M; Dykstra, Linda A et al. (2005) Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement. J Pharmacol Exp Ther 315:449-57
Walker, Ellen A; Picker, Mitchell J; Granger, Arthur et al. (2004) Effects of opioids in morphine-treated pigeons trained to discriminate among morphine, the low-efficacy agonist nalbuphine, and saline. J Pharmacol Exp Ther 310:150-8
Bohn, L M; Dykstra, L A; Lefkowitz, R J et al. (2004) Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol Pharmacol 66:106-12
Carroll, Ivy; Thomas, James B; Dykstra, Linda A et al. (2004) Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist. Eur J Pharmacol 501:111-9
Allen, Richard M; Granger, Arthur L; Dykstra, Linda A (2002) Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys. J Pharmacol Exp Ther 300:435-41

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